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NeoBiotechnologies
Neurofilament (H+L) (Neuronal Marker) Monoclonal Antibody (RT-97, NR-4)
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Product Details
MSM2-1201-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
RT-97, NR-4
Immunogen
Triton-X 100 insoluble proteins of rat brain (RT-97). Neurofilaments from porcine spinal cord (NR-4)
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 200 kDa neurofilament protein; 68 kDa neurofilament protein; hSTEp; intermediate filament; light molecular weight neurofilament protein; NEFH/NEFL; NEFL/NEFH; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament light polypeptide; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet H protein; Neurofilament triplet L protein; neurofilament, heavy polypeptide 200kDa; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; NF-H; NF-L; protein phosphatase 1, regulatory subunit 110; unnamed protein product
Gene Aliases: AI847934; CMT1F; CMT2CC; CMT2E; CMTDIG; KIAA0845; mKIAA0845; NEFH; NEFL; NF-H; NF-L; NF200; NF68; NFH; NFL; PPP1R110
UniProt ID: (Human) P12036, (Human) P07196, (Mouse) P19246, (Mouse) P08551, (Rat) P19527
Entrez Gene ID: (Human) 4744, (Pig) 100156492, (Chicken) 417020, (Chicken) 419528, (Human) 4747, (Pig) 100521224, (Rat) 24587, (Mouse) 380684, (Mouse) 18039, (Rat) 83613
structural constituent of cytoskeleton
protein binding
microtubule binding
kinesin binding
protein kinase binding
protein binding, bridging
dynein complex binding
structural constituent of postsynaptic intermediate filament cytoskeleton
tubulin binding
protein domain specific binding
identical protein binding
phospholipase binding
macromolecular complex binding
protein C-terminus binding
structural molecule activity
toxic substance binding
nutrient reservoir activity
protein heterodimerization activity
microtubule cytoskeleton organization
axonogenesis
anterograde axonal transport
retrograde axonal transport
response to toxic substance
peripheral nervous system axon regeneration
axonal transport of mitochondrion
spinal cord development
hippocampus development
cerebral cortex development
regulation of axon diameter
neurofilament bundle assembly
locomotion
response to peptide hormone
intermediate filament polymerization or depolymerization
intermediate filament organization
intermediate filament bundle assembly
neuron projection morphogenesis
positive regulation of axonogenesis
neuromuscular process controlling balance
protein polymerization
response to corticosterone
neurofilament cytoskeleton organization
regulation of synapse maturation
motor neuron apoptotic process
postsynaptic modulation of chemical synaptic transmission
postsynaptic intermediate filament cytoskeleton organization
response to sodium arsenite
response to acrylamide
negative regulation of motor neuron apoptotic process
axon development
cell projection assembly
intermediate filament cytoskeleton organization
peripheral nervous system neuron axonogenesis
regulation of organelle transport along microtubule
cellular response to leukemia inhibitory factor
negative regulation of neuron apoptotic process
ovarian follicle atresia
brain development
embryo development
axon regeneration
neuron projection development
cellular response to oxidative stress
response to cocaine
cellular response to estradiol stimulus
response to organic substance
response to organonitrogen compound
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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