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NeoBiotechnologies

NR5A2/LRH1 Monoclonal Antibody (PCRP-NR5A2-1B8)

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NR5A2/LRH1 Monoclonal Antibody (PCRP-NR5A2-1B8)

Product Details

2494-MSM2-P0

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/mL
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

PCRP-NR5A2-1B8

Immunogen

Recombinant human NR5A2 protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

20 µg

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control:HeLa or MCF-7 cells.

Cellular Location: Nucleus.

Target Information

Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTF; similar to nuclear hormone receptor; FTZ F1; FTZ F1beta; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; Liver receptor homolog 1; LRH-1; Nuclear receptor subfamily 5 group A member 2; nuclear receptor; similar to FTZ-F1; orphan nuclear receptor; unnamed protein product

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Gene Aliases: B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2

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UniProt ID: (Human) O00482

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Entrez Gene ID: (Human) 2494

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding phospholipid binding zinc ion binding lipid binding sequence-specific DNA binding metal ion binding sequence-specific double-stranded DNA binding
Process(es)
primary ovarian follicle growth inner cell mass cell differentiation positive regulation of T cell anergy chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis bile acid metabolic process hormone-mediated signaling pathway embryo development ending in birth or egg hatching tissue development neurogenesis intracellular receptor signaling pathway exocrine pancreas development positive regulation of glucocorticoid biosynthetic process negative regulation of chondrocyte differentiation somatic stem cell population maintenance embryonic cleavage positive regulation of T cell proliferation regulation of cell proliferation homeostatic process cholesterol homeostasis positive regulation of viral genome replication positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of T cell activation cartilage development Sertoli cell development pancreas morphogenesis acinar cell differentiation calcineurin-mediated signaling morula formation zygotic genome activation cellular response to leukemia inhibitory factor positive regulation of stem cell differentiation positive regulation of tendon cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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