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Invitrogen
IL-19 Monoclonal Antibody (350114)
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Product Details
MA5-61222
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
350114
Immunogen
E. coli-derived recombinant mouse IL-19, Leu25-Ala176
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine; il 19; IL-19; ILN; Interleukin; Interleukin-19; Interleukin19; MDA-1; melanoma differentiation associated protein-like protein; Melanoma differentiation-associated protein-like protein; NG.1; ZMDA1
Gene Aliases: IL-10C; IL19; MDA1; NG.1; ZMDA1
UniProt ID: (Human) Q9UHD0, (Mouse) Q8CJ70
Entrez Gene ID: (Human) 29949, (Mouse) 329244
apoptotic process
immune response
signal transduction
negative regulation of low-density lipoprotein particle clearance
reactive oxygen species metabolic process
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
inflammatory response
interleukin-6 biosynthetic process
positive regulation of JAK-STAT cascade
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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