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651166 is a mixture of monoclonal antibodies that target p0071 Multiepitope.
Detects a plaque protein (p0071) specific for a subtype of adherens junctions, with a molecular mass of 135 kD and is closely related to neurojungin/delta-catenin and ARVC (all belonging to the p120 armadillo subfamily). p0071 is specifically detected in the plaques of the composite junctions (area compositae) of cardiac intercalated disks, in puncta adhaerentia of single- and multi-layered epithelia and blood vessel endothelial cells.; it is, however, absent from desmosomes. This protein was also described as plakophilin 4.Reactivity on cultured cell lines: MCF-7, A431, CaCo-2, HT-29, PLC, 16HBE14o, HaCaT, SV80, U333 CG, 3T3, RVF-SMC, MH1C1.Positive control: MCF-7 cells.
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Armadillo-related protein; catenin 4; p0071; Plakophilin-4; similar to p0071 protein encoded by GenBank Accession Number X81889; armadillo repeat-containing protein similar to GT24 p120(cas), to beta catenin and to armadillo
Gene Aliases: 5031422I09Rik; 9430019K17Rik; Armrp; p0071; PKP4
UniProt ID: (Human) Q99569, (Mouse) Q68FH0
Entrez Gene ID: (Human) 8502, (Bovine) 281406, (Mouse) 227937
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