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Invitrogen

ANT1/ANT2/ANT3/ANT4 Polyclonal Antibody

View all (2) ANT1/ANT2/ANT3/ANT4 antibodies

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ANT1/ANT2/ANT3/ANT4 Polyclonal Antibody

Product Details

PA5-109394

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human ANT1 (NP_001142.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.65 mg/mL

Amount

165 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854805

Product Specific Information

Immunogen sequence: GMLPDPKNVH IFVSWMIAQS VTAVAGLVSY PFDTVRRRMM MQSGRKGADI MYTGTVDCWR KIAKDEGAKA FFKGAWSNVL RGMGGAFVLV LYDEIKKYV

Target Information

ANT1/2/3/4 (SLC25A4, SLC25A5, SLC25A6, SLC25A31) are members of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adenine nucleotid translocator 2 fibroblast isoform (ATP-ADP carrier protein); Adenine nucleotid translocator 2, fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocase 4; adenine nucleotide translocase-1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator 1, skeletal muscle; Adenine nucleotide translocator 2; adenine nucleotide translocator 2 (fibroblast); adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocator 2, fibroblast isoform (ATP-ADP carrier protein); Adenine nucleotide translocator 4; adenine nucleotide translocator), member 31; adenine nucleotide translocator), member 31-like; ADP,ATP carrier protein 1; ADP,ATP carrier protein 2; ADP,ATP carrier protein 4; ADP,ATP carrier protein, fibroblast isoform; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP.ATP translocase; ADP/ADT translocator protein; ADP/ATP carrier 1; ADP/ATP carrier protein; ADP/ATP translocase 1; ADP/ATP translocase 2; ADP/ATP translocase 4; ANT 1; ANT 2; ANT 4; heart/skeletal muscle ATP/ADP translocator; mANC1; mitochondrial adenine nucleotide translocator; Mitochondrial S-adenosylmethionine carrier protein; mitochondrial S-adenosylmethionine transporter; progressive external ophthalmoplegia 2; progressive external ophthalmoplegia 3; S-adenosylmethionine mitochondrial carrier protein; SAM carrier; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 31-like; solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator) member 4 isoform SLC25A4_1; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator) member 4 isoform SLC25A4_2; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator) member 4 isoform SLC25A4_3; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26; solute carrier family 25 (S-adenosylmethionine carrier), member 26; Solute carrier family 25 member 26; Solute carrier family 25 member 31; Solute carrier family 25 member 4; Solute carrier family 25 member 5; solute carrier family 25, member 26; Sperm flagellar energy carrier protein; SZFULLNAME2; unnamed protein product

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Gene Aliases: 1700034J06Rik; 2F1; 4930433D19Rik; 4933433F13Rik; AAC1; AAC2; AAC4; Anc1; ANT; ANT 1; ANT 4; ANT1; ANT2; ANT4; AU019225; AW557176; COXPD28; D6Bwg0781e; MTDPS12; MTDPS12A; PEO2; PEO3; PEOA2; SAMC; SFEC; SFEC35kDa; SLC25A26; SLC25A31; SLC25A4; SLC25A5; Slc25a6; SZGENESYMBOL2; T1; T2; T3

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UniProt ID: (Human) Q70HW3, (Human) Q9H0C2, (Human) P12235, (Human) P05141, (Mouse) Q5U680, (Mouse) Q3V132, (Rat) Q05962, (Mouse) P48962, (Rat) Q09073, (Mouse) P51881

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Entrez Gene ID: (Human) 115286, (Human) 83447, (Human) 291, (Human) 292, (Mouse) 67582, (Rat) 362403, (Rat) 689108, (Mouse) 73333, (Rat) 85333, (Mouse) 11739, (Rat) 25176, (Mouse) 11740

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Function(s)
S-adenosyl-L-methionine transmembrane transporter activity antiporter activity S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ATP:ADP antiporter activity protein binding hydrogen ion transmembrane transporter activity adenine transmembrane transporter activity oxidative phosphorylation uncoupler activity adenine nucleotide transmembrane transporter activity RNA binding ubiquitin protein ligase binding transporter activity enzyme binding poly(A) RNA binding mitochondrial carrier protein transfer/carrier protein
Process(es)
ion transport S-adenosyl-L-methionine transport purine nucleoside transmembrane transport macromolecule methylation L-alpha-amino acid transmembrane transport mitochondrial S-adenosyl-L-methionine transmembrane transport male meiosis I spermatogenesis cell differentiation regulation of mitochondrial membrane permeability transmembrane transport mitochondrial ADP transmembrane transport negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway mitochondrial ATP transmembrane transport mitochondrial genome maintenance generation of precursor metabolites and energy apoptotic mitochondrial changes adenine transport ADP transport negative regulation of necroptotic process positive regulation of mitophagy hydrogen ion transmembrane transport adaptive thermogenesis chromosome segregation positive regulation of cell proliferation B cell differentiation erythrocyte differentiation adenine nucleotide transport cellular response to leukemia inhibitory factor transport S-adenosyl-L-methionine transmembrane transport liver development heart development aging negative regulation of cardiac muscle cell apoptotic process positive regulation of cell growth involved in cardiac muscle cell development response to interleukin-1 negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of oxidative phosphorylation uncoupler activity
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