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Invitrogen
Human RbAp46 (aa 1-13) Synthetic Peptide
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Product Details
PEP-083
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-083 is a 13 amino acid synthetic peptide whose sequence corresponds to residues 1-13 of human RbAp46 with a carboxy-terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): M1-A-S-K-E-M-F-E-D-T-V-E-E13-C
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous RbAp46, catalog # PA1-868 and PA1.1-868. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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