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Alomone Labs, LTD
Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 4
Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (extracellular) Antibody (ANC-004-25UL) in IHC (F)
Expression of nAChR alpha 4 in rat cerebellum - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (extracellular) Antibody (#ANC-004), (1:200). A. Expression of nAChR alpha 4 (green) was visualized in rat cerebellum. Purkinje cells were positive for nAChR alpha 4 (arrows). B. The same section was stained for ... View More
Product Details
ANC-004-25UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)DLVNMHSRVDQLD, corresponding to amino acid residues 190-202 of human nAChR alpha 4, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a4 nicotinic receptor; acetylcholine receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; alpha4 nAChR; alpha4-nAChR; cholinergic receptor; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha 4 subunit; cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA 4; nAChR alpha 4; Neuronal acetylcholine receptor subunit alpha-4; Neuronal nicotinic acetylcholine receptor alpha 4 subunit; neuronal nicotinic acetylcholine receptor alpha-4 subunit; unnamed protein product
Gene Aliases: Acra-4; Acra4; BFNC; CHRNA4; EBN; EBN1; ENFL1; NACHR; NACHRA4; NACRA4; NARAC
UniProt ID: (Human) P43681, (Mouse) O70174, (Rat) P09483
Entrez Gene ID: (Human) 1137, (Mouse) 11438, (Rat) 25590
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
protein binding
ligand-gated ion channel activity
acetylcholine receptor activity
acetylcholine-gated cation channel activity
acetylcholine binding
ATP-dependent chromatin remodeler activity
acetylcholine-activated cation-selective channel activity
drug binding
protein heterodimerization activity
ligand-gated ion channel
action potential
response to hypoxia
DNA repair
chromatin remodeling
ion transport
calcium ion transport
response to oxidative stress
signal transduction
chemical synaptic transmission
synaptic transmission, cholinergic
neuromuscular synaptic transmission
regulation of dopamine secretion
sensory perception of pain
ion transmembrane transport
response to nicotine
behavioral response to nicotine
B cell activation
regulation of membrane potential
neurological system process
cognition
membrane depolarization
excitatory postsynaptic potential
inhibitory postsynaptic potential
acetylcholine receptor signaling pathway
presynaptic modulation of chemical synaptic transmission
transport
cation transport
respiratory gaseous exchange
locomotory behavior
positive regulation of dopamine secretion
exploration behavior
protein heterooligomerization
cation transmembrane transport
regulation of acetylcholine-gated cation channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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