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Invitrogen
Factor VIII Monoclonal Antibody (F8-5.5.72)
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FIGURE: 1 / 9
Factor VIII Antibody (MA5-45984) in ICC/IF
PloS one 2016 -
Fig 10 Less FVIII is bound to secreted/anchored ULVWF strings from stimulated HUVECs compared to GMVECs. HUVECs were stimulated with 100muM histamine for 2 min. Cells were then stained as described in the legend for Fig 9 with rabbit anti-VWF plus chicken anti-rabbit IgG AF-488 (green), and with mouse monoclonal anti-FVIII plus goat anti-mouse IgG AF-647 (red). Panels (A, C and E) show representative ULVWF ... View More
Product Details
MA5-45984
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
F8-5.5.72
Immunogen
Purified human Factor VIII.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
1 mg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-10589 detects full-length human Factor VIII. This antibody does not cross-react with von Willebrand factor.
MA1-10589 has been successfully used in ELISA and Western blot applications.
The MA1-10589 immunogen is purified human Factor VIII.
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; Factor 8; factor VIII; factor VIII F8B; factor8; preprocoagulation factor VIII:C; Procoagulant component; RP11-115M6.7; unnamed protein product
Gene Aliases: AHF; DXS1253E; F8; F8B; F8C; FVIII; HEMA; THPH13
UniProt ID: (Human) P00451
Entrez Gene ID: (Human) 2157
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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