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Proteintech
EIF3B Polyclonal Antibody
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Product Details
10319-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EIF3B Fusion Protein Ag0386 (381-562 aa encoded by BC001173)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FSPCERYLV TFSPLMDTQD DPQAIIIWDI LTGHKKRGFH CESSAHWPIF KWSHDGKFFA RMTLDTLSIY ETPSMGLLDK KSLKISGIKD FSWSPGGNII AFWVPEDKDI PARVTLMQLP TRQEIRVRNL FNVVDCKLHW QKNGDYLCVK VDRTPKGTQG VVTNFEIFRM REKQVPVDVV EMK (381-562 aa encoded by BC001173)
Target Information
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eIF-3-eta; eIF-3-eta {ECO:0000255|HAMAP-Rule:MF_03001}; eIF3 p110; eIF3 p116; eIF3b; eIF3b {ECO:0000255|HAMAP-Rule:MF_03001}; Eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001}; Eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001}; eukaryotic translation initiation factor 3, subunit 9 (eta); eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; hPrt1; MGC104664; MGC131875; protein synthesis 1; Prt1 homolog; unnamed protein product
Gene Aliases: AL033316; AL033334; AL033369; AW208965; D5Wsu45e; EIF3-ETA; EIF3-P110; EIF3-P116; EIF3B; EIF3S9; PRT1
UniProt ID: (Human) P55884, (Mouse) Q8JZQ9, (Rat) Q4G061
Entrez Gene ID: (Human) 8662, (Mouse) 27979, (Rat) 288516
formation of cytoplasmic translation initiation complex
cytoplasmic translational initiation
translation
translational initiation
regulation of translational initiation
IRES-dependent viral translational initiation
viral translational termination-reinitiation
formation of translation preinitiation complex
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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