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HLA-E Polyclonal Antibody

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HLA-E Polyclonal Antibody

Product Details

15008-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HLA-E Fusion Protein Ag6703 (23-303 aa encoded by BC002578)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Amount

40.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody MEM-E/08 recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results revealed that antibody is remarkably specific for HLA-E, only with weak cross-reactivity with following classical MHC Class I molecules (MHC Class Ia): HLA-A24, -B7, -B27, -B51, -B54, -C7.

Immunogen sequence: SHSLKYFHT SVSRPGRGEP RFISVGYVDD TQFVRFDNDA ASPRMVPRAP WMEQEGSEYW DRETRSARDT AQIFRVNLRT LRGYYNQSEA GSHTLQWMHG CELGPDRRFL RGYEQFAYDG KDYLTLNEDL RSWTAVDTAA QISEQKSNDA SEAEHQRAYL EDTCVEWLHK YLEKGKETLL HLEPPKTHVT HHPISDHEAT LRCWALGFYP AEITLTWQQD GEGHTQDTEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPEPV TLRWKPASQP TI (23-303 aa encoded by BC002578)

Target Information

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DAMA-277I14.1; DAQB-90C11.16; DKFZp686P19218; FLJ26655; HLA class I histocompatibility antigen, alpha chain E; HLA-E class I protein precursor; MHC 1; MHC class I antigen E; MHC class Ib antigen; MHC1; non-classical MHC class I antigen; nonclassical MHC class I antigen; unnamed protein product

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Gene Aliases: HLA-6.2; HLA-E; HLAE; QA1

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UniProt ID: (Human) P13747

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Entrez Gene ID: (Human) 3133

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Function(s)
receptor binding protein binding beta-2-microglobulin binding MHC class I protein binding peptide antigen binding T cell receptor binding natural killer cell lectin-like receptor binding receptor agonist activity
Process(es)
positive regulation of antibody-dependent cellular cytotoxicity positive regulation of T cell mediated cytotoxicity natural killer cell mediated immunity adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent natural killer cell tolerance induction positive regulation of immunoglobulin production regulation of natural killer cell mediated immunity positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell cytokine production immune response signal transduction antibacterial humoral response antigen processing and presentation positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of TRAIL production positive regulation of tumor necrosis factor production negative regulation of natural killer cell activation positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation CD8-positive, alpha-beta T cell activation negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity innate immune response negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity defense response to Gram-positive bacterium positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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