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Proteintech
KLHL22 Polyclonal Antibody
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Product Details
16214-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLHL22 Fusion Protein Ag9212 (81-634 aa encoded by BC015923)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GGLKEMEQE EVLIHGVSYN AMCQILHFIY TSELELSLSN VQETLVAACQ LQIPEIIHFC CDFLMSWVDE ENILDVYRLA ELFDLSRLTE QLDTYILKNF VAFSRTDKYR QLPLEKVYSL LSSNRLEVSC ETEVYEGALL YHYSLEQVQA DQISLHEPPK LLETVRFPLM EAEVLQRLHD KLDPSPLRDT VASALMYHRN ESLQPSLQSP QTELRSDFQC VVGFGGIHST PSTVLSDQAK YLNPLLGEWK HFTASLAPRM SNQGIAVLNN FVYLIGGDNN VQGFRAESRC WRYDPRHNRW FQIQSLQQEH ADLSVCVVGR YIYAVAGRDY HNDLNAVERY DPATNSWAYV APLKREVYAH AGATLEGKMY ITCGRRGEDY LKETHCYDPG SNTWHTLADG PVRRAWHGMA TLLNKLYVIG GSNNDAGYRR DVHQVACYSC TSGQWSSVCP LPAGHGEPGI AVLDNRIYVL GGRSHNRGSR TGYVHIYDVE KDCWEEGPQL DNSISGLAAC VLTLPRSLLL EPPRGTPDRS QADPDFASEV MSVSDWEEFD NSSED (81-634 aa encoded by B C015923)
Target Information
KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophila kelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Em:AC005500.4; kelch-like 22; Kelch-like protein 22; unnamed protein product
Gene Aliases: 2610318I18Rik; KELCHL; KLHL22; RGD1306288
UniProt ID: (Human) Q53GT1, (Mouse) Q99JN2, (Rat) D3ZZC3
Entrez Gene ID: (Human) 84861, (Mouse) 224023, (Rat) 303792
mitotic sister chromatid segregation
protein monoubiquitination
cell cycle
mitotic nuclear division
mitotic spindle assembly checkpoint
protein ubiquitination
cell division
negative regulation of T cell mediated immune response to tumor cell
positive regulation of T cell mediated immune response to tumor cell
ubiquitin-dependent protein catabolic process
negative regulation of autophagy
positive regulation of cell growth
cellular response to nutrient levels
negative regulation of type I interferon production
positive regulation of type I interferon production
cellular response to amino acid starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of T cell activation
positive regulation of T cell activation
cellular response to amino acid stimulus
cellular response to leucine
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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