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Proteintech
Collagen Type IV Polyclonal Antibody
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FIGURE: 1 / 4
Collagen Type IV Antibody (55131-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using (Product # 55131-1-AP) (Collagen Type IV antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
55131-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific for collagen, type IV, alpha.
Target Information
Collagen IV is a type of collagen protein that is a major component of the basement membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a matrix-derived inhibitor of angiogenesis and tumor growth; a3(IV)NC1; arresten; canstatin; COL4A1 NC1 domain; COL4A2 NC1 domain; COL4A3 NC1 domain; Collagen 4; Collagen alpha-1(IV) chain; collagen alpha-2 type IV; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen type IV alpha 5 chain; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; contains COL4A1 NC1 domain; dA149D17.3; dA24A23.1; dJ889N15.4 (Collagen Alpha 6(IV)); Goodpasture antigen; matrix-derived inhibitor of angiogenesis and tumor growth; non-collagenous 1 domain from alpha 1 chain of type IV collagen; pro-alpha-1(IV); procollagen alpha-1 type IV; soluble Col4A1 protein; structural non-collagenous NC1 domain; a6[IV]NC1; tumstatin; Type IV Collagen; unnamed protein product
Gene Aliases: ASLN; ATS; ATS1; ATS2; ATS3; ATS3A; ATS3B; BFH; BFH1; BFH2; BSVD; BSVD1; BSVD2; CA44; CA54; COL4A1; COL4A1s; COL4A2; COL4A3; COL4A4; COL4A5; COL4A6; CXDELq22.3; DELXq22.3; DFNX6; ICH; PADMAL; POREN2; RATOR
UniProt ID: (Human) P02462, (Human) P08572, (Human) Q01955, (Human) P53420, (Human) P29400, (Human) Q14031
Entrez Gene ID: (Human) 1282, (Human) 1284, (Human) 1285, (Human) 1286, (Human) 1287, (Human) 1288
cell adhesion
extracellular matrix organization
collagen-activated tyrosine kinase receptor signaling pathway
cellular response to amino acid stimulus
angiogenesis
patterning of blood vessels
brain development
neuromuscular junction development
epithelial cell differentiation
blood vessel morphogenesis
retinal blood vessel morphogenesis
renal tubule morphogenesis
basement membrane organization
glomerular basement membrane development
transcription, DNA-templated
response to activity
negative regulation of angiogenesis
endodermal cell differentiation
cellular response to transforming growth factor beta stimulus
cell surface receptor signaling pathway
sensory perception of sound
negative regulation of cell proliferation
endothelial cell apoptotic process
negative regulation of vascular endothelial cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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