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Proteintech
FBP1 Monoclonal Antibody (2G4E4)
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Product Details
68446-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2G4E4
Immunogen
FBP1 fusion protein Ag3837
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
Target Information
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 3; EC 3.1.3.11; FBP 1; FBPase 1; FBPase 3; FBPase brain isoform; FBPase liver; fructose 1,6-bisphosphatase; fructose 1,6-bisphosphatase (EC 3.1.3.11); fructose-1; fructose-1,6- biphosphatase 1; Fructose-1,6-bisphosphatase 1; Fructose-1,6-bisphosphatase isozyme 3; Fructose-16- biphosphatase; GIG17; growth-inhibiting protein 17; Liver FBPase; unnamed protein product
Gene Aliases: FBP; Fbp-2; FBP1; Fbp2; Fbp3; Fdp
UniProt ID: (Human) P09467, (Pig) P00636, (Rat) P19112, (Mouse) Q9QXD6
Entrez Gene ID: (Human) 2203, (Pig) 397038, (Rat) 24362, (Mouse) 14121
catalytic activity
protein binding
AMP binding
hydrolase activity
phosphatase activity
fructose 1,6-bisphosphate 1-phosphatase activity
phosphoric ester hydrolase activity
identical protein binding
metal ion binding
monosaccharide binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
RNA polymerase II transcription factor binding
carbohydrate phosphatase
negative regulation of transcription from RNA polymerase II promoter
carbohydrate metabolic process
fructose metabolic process
fructose 6-phosphate metabolic process
gluconeogenesis
regulation of gluconeogenesis
negative regulation of cell growth
fructose 1,6-bisphosphate metabolic process
response to nutrient levels
cellular response to insulin stimulus
negative regulation of glycolytic process
negative regulation of Ras protein signal transduction
cellular response to magnesium ion
cellular response to cAMP
cellular response to xenobiotic stimulus
cellular hyperosmotic salinity response
cellular hypotonic salinity response
cellular response to raffinose
cellular response to phorbol 13-acetate 12-myristate
dephosphorylation
cellular response to drug
protein homotetramerization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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