Silencer™ Select Human Long Non-coding RNA (lncRNA) siRNA Library

Long noncoding RNAs (lncRNAs) have gained interest in recent years as they have been implicated in genomic regulation, cellular housekeeping functions, developmental processes and disease. The Silencer™ Select Human Long Noncoding RNA (lncRNA) siRNA Library contains 15,081 Ambion™ Silencer Select siRNAs targeting 5,027 lncRNAs as identified in GENCODE v22. The Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library is designed against targeted transcripts aligned to the entire genome, maximizing prediction and coverage across alternatively spliced transcripts. Silencer Select siRNAs are designed with Thermo Fisher Scientific’s leading design algorithms and locked nucleic acid (LNA) chemical modifications to help ensure efficacy, specificity and potency. This in turn provides a powerful platform for achieving accurate and consistent phenotype data from RNAi screens in the discovery and elucidation of lncRNAs.

• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our 96- and 384-well arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Why use the Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library?
Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized with latest design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes (learn more). The Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality backed by the best in industry guarantee (learn more about the guarantee).

Silencer Select siRNA libraries empower you with highly potent siRNAs to maximize discovery with even less
Ambion Silencer Select siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potent Silencer Select siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. The Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).

Flexibility to meet your workflow needs
Thermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.com.