(a) Silencer Select: Life Technologies guarantees that when you purchase two (2) Silencer Select pre-designed siRNA to the same target, then those two siRNAs will silence the target mRNA by 70% or more. To qualify for the guarantee, siRNAs must have been transfected at ≥5 nM and mRNA levels detected 48h post-transfection. Customers must also show ≥70%knockdown with a validated Silencer Select positive control siRNA in the same experiment to demonstrate transfection efficiency. We recommend the use of a Silencer Select non-targeting negative control to normalize mRNA knockdown. If the guaranteed level of knockdown is not observed while an appropriate positive control is successful, a new Silencer Select siRNA will be provided as afree-of-charge replacement. Requests for replacement product must be made within one hundred and eighty (180) days from the date of delivery of the Silencer Select pre-designed siRNAs. This guarantee does not extend to any replacement product nor to siRNAs designed to silence lncRNAs.

(b) Stealth: Life Technologies guarantees that when you purchase three (3) Stealth pre-designed RNAi reagents to the same target, at least two of those reagents will silence the target mRNA by 70% or more. To qualify for the guarantee, Stealth RNAi must have been transfected at ≥20 nM and mRNA levels detected 48h post-transfection. Customers must also show ≥70%knockdown with a Stealth positive control reagent in the same experiment to demonstrate transfection efficiency. We recommend the use of a Stealth negative control to normalize message knockdown. If the guaranteed level of knockdown is not observed while an appropriate positive control is successful, a new Stealth reagentwill be provided as a free-of-charge replacement. Requests for replacement product must be made within one hundred and eighty (180) days from the date of delivery of the Stealth pre-designed reagents. This guarantee does not extend to any replacement product.

(c) Silencer: Life Technologies guarantees that when you purchase three (3) Silencer pre-designed siRNAs to the same target, at least two of the siRNAs will silence the target mRNA by 70% or more. To qualify for the guarantee, siRNAs must have been transfected at 100 nM and mRNA levels detected 48h post-transfection. Customers must also show ≥70% knockdown with a validated Silencer positive control siRNA in the same experiment to demonstrate transfection efficiency. We recommend the use of a Silencer non-targeting negative control to normalize mRNA knockdown. If the guaranteed level of knockdown is not observed while an appropriate positive control is successful, a new Silencer siRNA will be provided as a free-of-charge replacement. Requests for replacement product must be made within one hundred and eighty (180) days from the date of delivery of the Silencer pre-designed siRNAs. This guarantee does not extend to any replacement product.

siRNA videos

Meet the inventor: Susan Magdaleno discusses Silencer Select siRNA technology

Dr. Gavin Robertson describes how Silencer Select siRNA technology is advancing melanoma research.

siRNA publications