Short/Small Interfering RNAs

High quality siRNA reagents for potent gene silencing

RNA interference (RNAi) using small, interfering RNA (siRNA) is the best way to effectively knock down gene expression to study protein function in a wide range of cell types.

  • Choose from guaranteed, pre-designed siRNAs targeting human, mouse, or rat
  • Validated siRNAs available against key human and mouse targets
  • Specificity-enhanced siRNA reduces the likelihood of off-target effects

Search pre-designed siRNA

Choose from our pre-designed siRNA product lines

 Silencer Select siRNAStealth RNAi siRNASilencer siRNA
 RECOMMENDED
Highest knockdown, fewest off-targets
Good knockdown, reduced off-targetsCost-effective, guaranteed siRNA
Potency (recommended working conc.) 5 nM20 nM50 nM
Silencing guarantee
Learn more
2 of 2 siRNA 2 of 3 siRNA2 of 3 siRNA
Target specificityHighestHighModerate
Chemical modifications, length
  • LNA-modified
  • 19-bp duplex
  • 2 nt overhangs
  • Modified
  • 25-bp duplex
  • no overhangs
  • Unmodified
  • 19-bp duplex
  • 2 nt overhangs
Gene types targetedProtein-coding genesProtein-coding genes
siRNA LibrariesNot available
Target speciesHuman, mouse, rat
(Other species: order custom designs)
Custom siRNA ordering toolCustom Silencer Select siRNACustom Stealth RNAi siRNA Custom Silencer siRNA

New to siRNAComplete the RNAi workflow with optimal siRNA delivery and tools for mRNA knockdown detection!


siRNA videos

Meet the inventor: Susan Magdaleno discusses Silencer Select siRNA technology

Dr. Gavin Robertson describes how Silencer Select siRNA technology is advancing melanoma research.

Questions?

If you have any questions on products or ordering, please contact us at RNAiSupport@thermofisher.com