A Solution For Successful In Vivo RNAi

In vivo RNAi experiments are more challenging than their in vitro counterparts due to the high levels of ribonucleases present in all body fluids. These added challenges necessitate the use of the RNase resistant Ambion® In Vivo siRNAs to obtain reproducible results in vivo. Ambion® In Vivo siRNAs retain all the characteristics of Silencer Select including potency, specificity and efficacy and provide an enhanced stability and safety profile for animal studies.

Which In Vivo siRNA is right for you?

  Order now Order now Order now
  Cost-effective siRNA High knock-down Highest knock-down, prolonged nuclease stability
  Silencer® siRNA
Learn more >
Stealth RNAi™ siRNA
Learn more >
Ambion® In Vivo siRNA
Relative % Knockdown Moderate High Highest
Nuclease Resistance (w/o Delivery Agent) <5 min in 90% Mouse Serum ~12 hours in 90% Mouse Serum >48 hours in 90% Mouse Serum
Recommended Dosing with Invivofectamine 3.0 >1 mg/kg ~1 mg/kg ~1 mg/kg
Target Specificity Moderate High Highest
Innate Immune Response Minimum Minimized through chemical modifications Minimized through chemical modifications
Molecular Format Unmodified 21-bp duplex with overhangs Modified 25-bp duplex with no overhangs LNA modified 21-bp duplex with overhangs
Custom Tool Custom Silencer® siRNA Custom Stealth RNAi™ siRNA Custom Ambion® In Vivo siRNA
Catalog #
AM16231: siRNA In Vivo Custom 250 nmol 100001866: RNA - Stealth 20 nmol In Vivo 4457308: Ambion In Vivo Pre-DGN HPLC, 250 nmol

Additional siRNA ordering tools:


If you have any questions on products or ordering, please contact us at