A Solution For Successful In Vivo RNAi
In vivo RNAi experiments are more challenging than their in vitro counterparts due to the high levels of ribonucleases present in all body fluids. These added challenges necessitate the use of the RNase resistant Ambion® In Vivo siRNAs to obtain reproducible results in vivo. Ambion® In Vivo siRNAs retain all the characteristics of Silencer Select including potency, specificity and efficacy and provide an enhanced stability and safety profile for animal studies.
Which In Vivo siRNA is right for you?
|Cost-effective siRNA||High knock-down||Highest knock-down, prolonged nuclease stability|
|Order now||Order now||Order now|
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|Stealth RNAi™ siRNA
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|Ambion® In Vivo siRNA|
|Relative % Knockdown||Moderate||High||Highest|
|Nuclease Resistance (w/o Delivery Agent)||<5 min in 90% Mouse Serum||~12 hours in 90% Mouse Serum||>48 hours in 90% Mouse Serum|
|Recommended Dosing with Invivofectamine 3.0||>1 mg/kg||~1 mg/kg||~1 mg/kg|
|Innate Immune Response||Minimum||Minimized through chemical modifications||Minimized through chemical modifications|
|Molecular Format||Unmodified 21-bp duplex with overhangs||Modified 25-bp duplex with no overhangs||LNA modified 21-bp duplex with overhangs|
|Custom Tool||Custom Silencer® siRNA||Custom Stealth RNAi™ siRNA||Custom Ambion® In Vivo siRNA|
|AM16231: siRNA In Vivo Custom 250 nmol||100001866: RNA - Stealth 20 nmol In Vivo||4457308: Ambion In Vivo Pre-DGN HPLC, 250 nmol|