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Abnova

PTPN6 Polyclonal Antibody, MaxPab™

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PTPN6 Polyclonal Antibody, MaxPab™

Product Details

H00005777-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PTPN6 (NP_002822.2, 1 a.a. approximately 595 a.a) full-length human protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Cell lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL NCSDPTSERW YHGHMSGGQA ETLLQAKGEP WTFLVRESLS QPGDFVLSVL SDQPKAGPGS PLRVTHIKVM CEGGRYTVGG LETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KGKNRYKNIL PFDHSRVILQ GRDSNIPGSD YINANYIKNQ LLGPDENAKT YIASQGCLEA TVNDFWQMAW QENSRVIVMT TREVEKGRNK CVPYWPEVGM QRAYGPYSVT NCGEHDTTEY KLRTLQVSPL DNGDLIREIW HYQYLSWPDH GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ENISTKGLDC DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEVLQSQK GQESEYGNIT YPPAMKNAHA KASRTSSKHK EDVYENLHTK NKREEKVKKQ RSADKEKSKG SLKRK

Target Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70Z-SHP; EC 3.1.3.48; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; motheaten; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTPTY-42; SH-PTP1; SHP-1; Tyrosine-protein phosphatase non-receptor type 6; unnamed protein product

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Gene Aliases: 70Z-SHP; HCP; HCPH; HPTP1C; me; PTP-1C; PTP1C; PTPN6; PTPTY-42; SH-PTP1; SHP-1; SHP-1L; SHP1

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UniProt ID: (Human) P29350, (Mouse) P29351

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Entrez Gene ID: (Human) 5777, (Mouse) 15170

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Function(s)
phosphotyrosine binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding hydrolase activity SH3 domain binding protein kinase binding SH2 domain binding cell adhesion molecule binding phosphorylation-dependent protein binding phosphatase activity natural killer cell lectin-like receptor binding protein phosphatase
Process(es)
MAPK cascade mitotic cell cycle pattern recognition receptor signaling pathway hematopoietic progenitor cell differentiation neutrophil activation involved in immune response cytoplasmic pattern recognition receptor signaling pathway negative regulation of humoral immune response mediated by circulating immunoglobulin protein dephosphorylation G-protein coupled receptor signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of angiogenesis peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cell differentiation platelet formation T cell costimulation negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of mast cell activation involved in immune response positive regulation of cell adhesion mediated by integrin peptidyl-tyrosine dephosphorylation intracellular signal transduction megakaryocyte development T cell proliferation T cell activation negative regulation of T cell proliferation natural killer cell mediated cytotoxicity regulation of apoptotic process negative regulation of MAPK cascade regulation of B cell differentiation positive regulation of angiogenesis negative regulation of innate immune response T cell receptor signaling pathway B cell receptor signaling pathway negative regulation of B cell receptor signaling pathway negative regulation of T cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling regulation of type I interferon-mediated signaling pathway regulation of ERK1 and ERK2 cascade platelet aggregation inflammatory response to wounding negative regulation of inflammatory response to wounding CD27 signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of neutrophil activation epididymis development regulation of G1/S transition of mitotic cell cycle signal transduction cell proliferation positive regulation of phosphatidylinositol 3-kinase signaling dephosphorylation abortive mitotic cell cycle negative regulation of MAP kinase activity negative regulation of peptidyl-tyrosine phosphorylation
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