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Invitrogen
TRPM7 Polyclonal Antibody
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FIGURE: 1 / 1
TRPM7 Antibody (PA5-87618) in WB
Western blot analysis of TRPM7 in mouse skeletal muscle. Samples were incubated with TRPM7 Polyclonal antibody (Product # PA5-87618) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-87618
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 756-855 of human TRPM7 (NP_0601423)
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Amount
96 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NSWYKVILSI LVPPAILLLE YKTKAEMSHI PQSQDAHQMT MDDSENNFQN ITEEIPMEVF KEVRILDSNE GKNEMEIQMK SKKLPITRKF YAFYHAPIVK; Positive Samples: Mouse skeletal muscle; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Channel kinase 1; Channel-kinase 1; FLJ20117; Long transient receptor potential channel 7; LTrpC-7; tr; Transient receptor potential cation channel subfamily M member 7; transient receptor potential M7; Transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK; TRMP7; TRP PLIK; TRP-PLIK
Gene Aliases: 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; CHAK; CHAK1; Ltpr7; LTrpC-7; Ltrpc7; Trpm7; TRPPLIK
UniProt ID: (Mouse) Q923J1
Entrez Gene ID: (Mouse) 58800
nucleotide binding
actin binding
protein kinase activity
protein serine/threonine kinase activity
ion channel activity
cation channel activity
calcium channel activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
myosin binding
metal ion binding
ion channel
transporter
protein phosphorylation
transport
ion transport
cation transport
calcium ion transport
memory
cellular magnesium ion homeostasis
programmed cell death
phosphorylation
calcium-dependent cell-matrix adhesion
actomyosin structure organization
positive regulation of apoptotic process
protein autophosphorylation
transmembrane transport
necroptotic process
calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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