Search
Proteintech
PICALM Monoclonal Antibody (1F6G7), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL488-67564
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F6G7
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTT
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CALM; Clathrin assembly lymphoid myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly protein; rCALM; unnamed protein product
Gene Aliases: CALM; CLTH; fit-1; Fit1; LAP; mKIAA4114; PAP180; PICALM
UniProt ID: (Human) Q13492, (Mouse) Q7M6Y3, (Rat) O55012
Entrez Gene ID: (Human) 8301, (Mouse) 233489, (Rat) 89816
SNARE binding
beta-amyloid binding
protein binding
phospholipid binding
1-phosphatidylinositol binding
phosphatidylinositol-4,5-bisphosphate binding
clathrin binding
small GTPase binding
clathrin heavy chain binding
cadherin binding
tau protein binding
low-density lipoprotein particle receptor binding
SH3 domain binding
clathrin adaptor activity
identical protein binding
vesicle coat protein
cellular iron ion homeostasis
endocytosis
receptor-mediated endocytosis
membrane budding
axonogenesis
learning or memory
negative regulation of gene expression
synaptic vesicle maturation
vesicle-mediated transport
endosomal transport
hemopoiesis
regulation of endocytosis
receptor internalization
regulation of protein localization
cargo loading into vesicle
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
regulation of receptor-mediated endocytosis
negative regulation of receptor-mediated endocytosis
clathrin coat assembly
dendrite morphogenesis
multicellular organismal iron ion homeostasis
protein-containing complex assembly
clathrin-mediated endocytosis
regulation of vesicle size
membrane bending
amyloid-beta clearance by transcytosis
regulation of beta-amyloid formation
positive regulation of beta-amyloid formation
regulation of amyloid precursor protein catabolic process
positive regulation of amyloid precursor protein catabolic process
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell surface
multicellular organism development
cell proliferation
regulation of protein transport
iron ion homeostasis
iron ion import into cell
positive regulation of neuron death
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support