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Invitrogen
Ricin alpha VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1088)
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Product Details
MA5-54269
Product Specifications
Species Reactivity
Plant
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1088
Immunogen
Recombinant Castor bean Ricin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
Ricin toxin (RCA60), is a 60 kDa glycoprotein that consists of two chains, A and B, covalently linked by disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essental for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A Chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from castor bean (Ricinus comunis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, alhough a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for bilogical warfare although it is less stable than other agents, such as anthrax.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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