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Abnova
CACNG3 Monoclonal Antibody (3E4)
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Product Details
H00010368-M01
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3E4
Immunogen
CACNG3 (NP_006530, 199 a.a. approximately 297 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: IYIEKHQQLR AKSHSEFLKK STFARLPPYR YRFRRRSSSR STEPRSRDLS PISKGFHTIP STDISMFTLS RDPSKITMGT LLNSDRDHAF LQFHNSTPK
Target Information
Calcium Channel gamma-3 is a member of voltage dependent calcium channels (VDCCs) which allows neurons to tailor calcium signaling to functionally discrete cellular regions. Although N-Type VDCCs exist before birth which is consistent with a role in migration, most N-Type VDCCs subunit expression is postnatal, and important in the genesis of synaptic transmission in discrete hippocampal fields. Calcium Channel gamma-3 is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. Further, Calcium Channel gamma-3 is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. Calcium Channel gamma-3 gene dysfunction is a susceptibility locus for childhood absence epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cacng2; CACNG3; CACNLB3; calcium channel, voltage-dependent, gamma subunit 3; CaVgamma3; Neuronal voltage-gated calcium channel gamma-3 subunit; TARP gamma-3; Transmembrane AMPAR regulatory protein gamma-3; unnamed protein product; Voltage-dependent calcium channel gamma-3 subunit; voltage-gated calcium channel gamma subunit
Gene Aliases: CACNG3
UniProt ID: (Human) O60359, (Rat) Q8VHX0
Entrez Gene ID: (Human) 10368, (Rat) 140724
protein targeting
ion transport
calcium ion transport
protein localization
transmission of nerve impulse
ion transmembrane transport
positive regulation of synaptic transmission, glutamatergic
calcium ion transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
neurotransmitter receptor localization to postsynaptic specialization membrane
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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