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ABCC4/ATP Binding Cassette Subfamily C Member 4 (Drug Target) Monoclonal Antibody (ABCC4/9019)
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FIGURE: 1 / 1
ABCC4/ATP Binding Cassette Subfamily C Member 4 (Drug Target) Antibody (10257-MSM3-P1ABX) in IHC (P)
Formalin-fixed, paraffin-embedded human prostate cancer stained with ABCC4 Mouse Monoclonal Antibody (ABCC4/9019). Inset: PBS instead of primary antibody; secondary only negative control.
Product Details
10257-MSM3-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
ABCC4/9019
Immunogen
Recombinant fragment (around aa1-200) of human ABCC4 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: but is barely detectable in liver. Widely expressed with particularly high levels in prostate
Cellular Location: Membrane.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; RP11-74A12.1; transporter; alternatively spliced; truncated; MRP/cMOAT-related ABC transporter; unnamed protein product
Gene Aliases: ABCC4; MOAT-B; MOATB; MRP4
UniProt ID: (Human) O15439
Entrez Gene ID: (Human) 10257
nucleotide binding
guanine nucleotide transmembrane transporter activity
protein binding
ATP binding
xenobiotic-transporting ATPase activity
prostaglandin transmembrane transporter activity
urate transmembrane transporter activity
purine nucleotide transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
bile acid-exporting ATPase activity
efflux transmembrane transporter activity
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
ATPase activity
glutathione transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
platelet degranulation
xenobiotic metabolic process
drug transmembrane transport
lipid transport
bile acid and bile salt transport
prostaglandin transport
urate transport
prostaglandin secretion
glutathione transmembrane transport
transmembrane transport
cilium morphogenesis
cAMP transport
leukotriene transport
anion transmembrane transport
export across plasma membrane
transport across blood-brain barrier
guanine nucleotide transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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