Pharma 24 Twin-Screw Extruder

The Thermo Scientific™ Pharma 24 Twin-Screw Extruder, with available HME and Twin-Screw Granulation (TSG) Application Sets, is ideal for continuous processing in research, development or production in the pharmaceutical industry. The Pharma 24 extruder drives reduced clean room area, consistent and controllable processing, reduced product changeover time, on-demand production, minimized scale-up risk and reliable cleaning. It is suitable for process analytical technology (PAT).

The Pharma 24 Twin-Screw Extruder features:

• A small footprint to take up less space in clean rooms
• Continuous operation which consumes fewer utilities than traditional batch processes
• High free volume screw design
• A small process inventory
• Lower ingredient consumption which reduces handling and operator exposure
• Segmented screws and barrel
• Removable screws and liners

PAT Compatibility: PAT can be applied to your process to monitor parts of theprocess such as homogeneity of mixing or moisture content to assure required product quality. The Pharma 24 Extruder can be used with a range of PAT instruments such as Thermo Scientific™ FT-NIR system.

Options: We offer a full range of GMP compliant ancillaries which are matched to the extruder performance. This downstream equipment can be integrated into the extruder control system.

For TSG configurations: available ancillaries include volumetric or gravimetric dosing feeders and liquid injection pumps.

In addition, self-contained units of either configuration can be operated with recirculating chillers to reduce water consumption.

TSG configuration recommended for:

• Wet granulation
• Dry/melt granulation

For HME configurations: available ancillaries include volumetric or gravimetric dosing feeders, air cooled conveyors for product cooling, strand and face-cut pelletizers to make pellets, or chill roll/flaker units for rapid product cooling and flaking.

HME configuration recommended for:

• Solubility enhancement
• Modified release
• Co-extrusion
• Drug delivery systems
• Biomedical products