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Citations et références (23)
Invitrogen™
BODIPY™ FL Prazosin
La prazosine est un antagoniste à haute affinité pour le récepteur a1-adrénergique. Le dérivé de prazosine BODIPY™ FL fluorescent vertAfficher plus
| Référence | Quantité |
|---|---|
| B7433 | 100 μg |
Référence B7433
Prix (EUR)
556,00
Each
Quantité:
100 μg
Prix (EUR)
556,00
Each
La prazosine est un antagoniste à haute affinité pour le récepteur a1-adrénergique. Le dérivé de prazosine BODIPY™ FL fluorescent vert peut être utilisé pour localiser et détecter un récepteur a1-adrénergique.
Usage exclusivement réservé à la recherche. Ne pas utiliser pour des procédures de diagnostic.
Spécifications
Type d’étiquetteColorants BODIPY
Formule moléculaireC28H32BF2N7O3
Gamme de produitsBODIPY
Quantité100 μg
Température de stockageStocker au congélateur (entre -5°C et -30°C) à l’abri de la lumière.
Conditions d’expéditionTempérature ambiante
Type de produitFL Prazosine
Unit SizeEach
Citations et références (23)
Citations et références
Abstract
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
Journal:Proc Natl Acad Sci U S A
PubMed ID:9380680
'Human P-glycoprotein (Pgp) confers multidrug resistance to cancer cells by ATP-dependent extrusion of a great many structurally dissimilar hydrophobic compounds. The manner in which Pgp recognizes these different substrates is unknown. The protein shows internal homology between its N- and C-terminal halves, each comprised of six putative transmembrane helices and
Multidrug transporter activity in lymphocytes.
Journal:Br J Pharmacol
PubMed ID:15492020
'Multidrug transporters play a dual role in haematopoietic cells, mediating the efflux of xenobiotics and regulating cell migration. For several reasons including the lack of specific antibodies, reports of multidrug transporter distribution on lymphocytes conflict. Murine B cells have been reported to completely lack transporter activity. Through analysis of parental
Release of amines from acidified stores following accumulation by Transport-P.
Journal:Br J Pharmacol
PubMed ID:11181426
'1. Transport-P is an uptake process for amines in peptidergic neurones of the hypothalamus. It differs from other uptake processes by its anatomical location in post-synaptic neurones, its functional properties and by the structure of its ligands. Transport-P accumulates amines in intracellular vesicles, derives its energy from the electrochemical proton
Visual detection of transport-P in peptidergic neurones.
Journal:Br J Pharmacol
PubMed ID:9138694
'1. Hypothalamic peptidergic neurones possess an uptake process for amines (transport-P), for which prazosin is a substrate. It is characterized by a paradoxical increase in the accumulation of [3H]-prazosin when the concentration of unlabelled prazosin is increased above 10(-7) M. This increase is due to activation of a proton-dependent, vacuolar-type
Pharmacological implications of cellular localization of alpha1-adrenoceptors in native smooth muscle cells.
Journal:J Auton Pharmacol
PubMed ID:10961735
'1. This study examines the cellular localization of alpha1-adrenoceptors and demonstrates that binding to intracellular receptive binding sites in native smooth muscle cells may influence the pharmacological profile of agonists or antagonists. The example tissue studied was rat basilar artery. 2. An alpha1-adrenoceptor antagonist and fluorescent analogue of prazosin, BODIPY-FL