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Abnova
NPY Monoclonal Antibody (3B5)
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Product Details
H00004852-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3B5
Immunogen
NPY (AAH29497, 29 a.a. approximately 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: YPSKPDNPGE DAPAEDMARY YSALRHYINL ITRQRYGKRS SPETLISDLL MRESTENVPR TRLEDPAMW
Target Information
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase, regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neuropeptide-Y; OTTHUMP00000201947; prepro-neuropeptide Y; Pro-neuropeptide Y; unnamed protein product
Gene Aliases: NPY; PYY4
UniProt ID: (Human) P01303
Entrez Gene ID: (Human) 4852
response to yeast
negative regulation of acute inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
chemical synaptic transmission
feeding behavior
regulation of blood pressure
positive regulation of cell proliferation
adult feeding behavior
positive regulation of cell-substrate adhesion
antibacterial humoral response
antifungal humoral response
central nervous system neuron development
cerebral cortex development
neuron projection development
positive regulation of appetite
regulation of nerve growth factor production
monocyte activation
innate immune response
negative regulation of blood pressure
positive regulation of dopamine metabolic process
short-day photoperiodism
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
intestinal epithelial cell differentiation
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of ERK1 and ERK2 cascade
regulation of presynaptic cytosolic calcium ion concentration
synaptic signaling via neuropeptide
positive regulation of eating behavior
positive regulation of nitric oxide metabolic process
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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