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Citations & References (14)
Invitrogen™
Muscimol, BODIPY™ TMR-X Conjugate
Muscimol is a powerful agonist of the GABAA receptor and has been widely used to reversibly inactivate localized groups ofRead more
| Catalog Number | Quantity |
|---|---|
| M23400 | 1 mg |
Catalog number M23400
Price (HKD)
4,265.00
Each
Quantity:
1 mg
Price (HKD)
4,265.00
Each
Muscimol is a powerful agonist of the GABAA receptor and has been widely used to reversibly inactivate localized groups of neurons. The BODIPY TMR-X muscimol conjugate, can be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces.
To make a concentrated stock solution, dissolve in either H2O, buffer or normal saline (∼1 mM) or high quality anhydrous DMSO (∼2 mM). DMSO stock solutions should be stored frozen, desiccated and protected from light. Aqueous stock solution should be used fresh.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Detection MethodFluorescence
Excitation/Emission543/572 nm
For Use With (Equipment)Fluorescence Microscope
Molecular FormulaC31H36BF2N5O5
Molecular Weight (g/mol)607.46
Product LineBODIPY
Quantity1 mg
Recommended StorageStore in freezer (-5°C to -30°C) and protect from light.
Shipping ConditionRoom Temperature
ColorYellow
Physical FormSolid
Product TypeAgonist
Unit SizeEach
Citations & References (14)
Citations & References
Abstract
Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment.
Journal:Biomaterials
PubMed ID:15576163
'The derivatization of surfaces with bioactive molecules is a research area of growing importance for cell and tissue engineering. Tetherable molecules used in such applications must contain an anchoring moiety as well as the biofunctional group, typically along with a spacer to prevent steric clashes between the target molecule and
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction.
Journal:Proc Natl Acad Sci U S A
PubMed ID:17190810
'Signaling in the nervous system requires matching of neurotransmitter receptors with cognate neurotransmitters at synapses. The vertebrate neuromuscular junction is the best studied cholinergic synapse, but the mechanisms by which acetylcholine is matched with acetylcholine receptors are not fully understood. Because alterations in neuronal calcium spike activity alter transmitter specification
Imaging the spread of reversible brain inactivations using fluorescent muscimol.
Journal:J Neurosci Methods
PubMed ID:18377997
Muscimol is a GABA A-agonist that causes rapid and reversible suppression of neurophysiological activity. Interpretations of the effects of muscimol infusions into the brain have been limited because of uncertainty about spread of the drug around the injection site. To solve this problem, the present study explored the use of
GABA(A) receptor binding and localization in the tiger salamander retina.
Journal:Vis Neurosci
PubMed ID:10750823
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the retina and also appears to act as a trophic factor regulating photoreceptor development and regeneration. Although the tiger salamander is a major model system for the study of retinal circuitry and regeneration, our understanding of GABA receptors in this species
A cross-modality enhancement of defensive flight via parvalbumin neurons in zona incerta.
Journal:Elife
PubMed ID:30985276