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Invitrogen
SEMA7A Monoclonal Antibody (238906)
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Product Details
MA5-61091
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
238906
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Semaphorin 7A, Gln45-Ala646
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors - plexin C1 and beta1 integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD108; CDw108; H-Sema K1; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; John-Milton-Hargen human blood group Ag; MGC126692; MGC126696; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; semaphorin 7A (John Milton Hagen blood group); semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Semaphorin K1; Semaphorin-7A; Semaphorin-K1; Semaphorin-L; unnamed protein product
Gene Aliases: 2900057C09Rik; CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; M-Sema-L; PFIC11; SEMA7A; SEMAK1; SEMAL; Semk1
UniProt ID: (Human) O75326, (Mouse) Q9QUR8
Entrez Gene ID: (Human) 8482, (Mouse) 20361
osteoblast differentiation
neural crest cell migration
inflammatory response
immune response
integrin-mediated signaling pathway
nervous system development
axon guidance
olfactory lobe development
cell differentiation
positive regulation of cell migration
neuron projection development
positive regulation of axon extension
axon extension
regulation of inflammatory response
negative chemotaxis
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
regulation of synapse maturation
positive regulation of protein phosphorylation
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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