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Invitrogen
HBEGF Monoclonal Antibody (125923)
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Product Details
MA5-61184
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
125923
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HB-EGF, Asp63-Leu148
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); hb egf; heparin-binding epidermal growth factor; Proheparin-binding EGF-like growth factor; unnamed protein product
Gene Aliases: DTR; DTS; DTSF; HBEGF; HEGFL
UniProt ID: (Human) Q99075
Entrez Gene ID: (Human) 1839
signal transduction
epidermal growth factor receptor signaling pathway
muscle organ development
regulation of heart contraction
positive regulation of cell proliferation
negative regulation of glycoprotein biosynthetic process
cell migration
positive regulation of cell growth
positive regulation of cell migration
wound healing, spreading of epidermal cells
ERBB2-EGFR signaling pathway
ERBB2-ERBB4 signaling pathway
positive regulation of smooth muscle cell proliferation
positive regulation of keratinocyte migration
positive regulation of protein kinase B signaling
cell chemotaxis
positive regulation of wound healing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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