Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)
Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)
Citations & References (3)
Thermo Scientific™

Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Thermo Scientific Pierce Sulfo-EMCS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends ofRead more
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Catalog NumberQuantity
2230750 mg
Catalog number 22307
Price (KRW)
485,000
キャンペーン価格
Ends: 31-Dec-2025
570,000
Save 85,000 (15%)
Each
Add to cart
Quantity:
50 mg
Request bulk or custom format
Price (KRW)
485,000
キャンペーン価格
Ends: 31-Dec-2025
570,000
Save 85,000 (15%)
Each
Add to cart
Thermo Scientific Pierce Sulfo-EMCS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).

Features of Sulfo-EMCS:

• Reactive groups: sulfo-NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• Sulfo-NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
• Non-cleavable
• Water-soluble (compare to EMCS)
• Aliphatic spacer offers low potential for eliciting an immune response

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
EMCS (N-ε-malemidocaproyl-oxysuccinimide ester)
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Cell PermeabilityNo
DescriptionSulfo-EMCS
FormPowder
Labeling MethodChemical Labeling
Molecular Weight (g/mol)410.33
PEGylatedNo
Product LinePierce
Quantity50 mg
Reactive MoietyMaleimide, Sulfo-NHS Ester
Shipping ConditionAmbient
SolubilityWater
Spacer Arm Length9.4 Å
Water SolubleYes
Chemical ReactivityAmine-Sulfhydryl
CleavableNo
Crosslinker TypeHeterobifunctional
FormatStandard
Product TypeCrosslinker
SpacerShort (<10 Å)
Unit SizeEach
Contents & Storage
Upon receipt store desiccated at 4°C.

Frequently asked questions (FAQs)

Can you provide the shelf-life for Sulfo-EMCS (N-&epsilon;-maleimidocaproyl-oxysulfosuccinimide ester)?

Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester) is covered under our general 1-year warranty and is guaranteed to be fully functional for 12 months from the date of shipment, if stored as recommended. Please see section 8.1 of our Terms & Conditions of Sale (https://www.thermofisher.com/content/dam/LifeTech/Documents/PDFs/Terms-and-Conditions-of-Sale.pdf) for more details.

Find additional tips, troubleshooting help, and resources within our Protein Purification and Isolation Support Center.

Citations & References (3)

Citations & References
Abstract
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.
Authors:Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai WP, Chilcote TJ
Journal:J Biol Chem
PubMed ID:16847063
'A comprehensive, unbiased inventory of synuclein forms present in Lewy bodies from patients with dementia with Lewy bodies was carried out using two-dimensional immunoblot analysis, novel sandwich enzyme-linked immunosorbent assays with modification-specific synuclein antibodies, and mass spectroscopy. The predominant modification of alpha-synuclein in Lewy bodies is a single phosphorylation at ... More
An on-chip thin film photodetector for the quantification of DNA probes and targets in microarrays.
Authors:Fixe F, Chu V, Prazeres DM, Conde JP
Journal:Nucleic Acids Res
PubMed ID:15148343
A flat microdevice which incorporates a thin-film amorphous silicon (a-Si:H) photodetector with an upper layer of functionalized SiO2 is used to quantify the density of both immobilized and hybridized DNA oligonucleotides labeled with a fluorophore. The device is based on the photoconductivity of hydrogenated amorphous silicon in a coplanar electrode ... More
Functionalization of poly(methyl methacrylate) (PMMA) as a substrate for DNA microarrays.
Authors:Fixe F, Dufva M, Telleman P, Christensen CB
Journal:Nucleic Acids Res
PubMed ID:14718554
A chemical procedure was developed to functionalize poly(methyl methacrylate) (PMMA) substrates. PMMA is reacted with hexamethylene diamine to yield an aminated surface for immobilizing DNA in microarrays. The density of primary NH2 groups was 0.29 nmol/cm2. The availability of these primary amines was confirmed by the immobilization of DNA probes ... More