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Alomone Labs, LTD
KISS1 Receptor (GPR54) (extracellular) Polyclonal Antibody, FITC
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FIGURE: 1 / 3
KISS1 Receptor (GPR54) (extracellular) Antibody (AKR-001-F-50UL) in Flow
Cell surface detection of KISS1R by direct flow cytometry in live intact human THP-1 monocytic leukemia cell line. Black line: Cells. Red line: Cells + Rabbit IgG Isotype Control-FITC (#RIC-001-F). Green line: Cells + Anti-KISS1 Receptor (GPR54) (extracellular)-FITC Antibody (#AKR-001-F) (5 µg).
Product Details
AKR-001-F-50UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide KEPTEPKFKGLRLE, corresponding to amino acid residues 18-31 of human PANX1. Intracellular, N-terminus.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: KEPTEPKFKGLRLE
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
GCPR54 is a galanin-like G protein coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the protein suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that it appears to play a role in the onset of puberty. GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor; G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; kiSS-; KiSS-1 receptor; KiSS-1R; Kisspeptins receptor; Metastin receptor; mOT7T175; orphan G protein-coupled receptor 54; orphan G protein-coupled receptor GPR54; rOT7T175
Gene Aliases: AXOR12; CPPB1; GPR54; HH8; HOT7T175; KiSS-1; KISS-1R; KISS1R
UniProt ID: (Human) Q969F8, (Mouse) Q91V45, (Rat) Q924U1
Entrez Gene ID: (Human) 84634, (Mouse) 114229, (Rat) 78976
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
positive regulation of hormone secretion
activation of MAPKK activity
chemical synaptic transmission
negative regulation of cell proliferation
calcium-mediated signaling
negative regulation of cell migration
arachidonic acid secretion
positive regulation of synaptic transmission
positive regulation of stress fiber assembly
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