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HMGB2 Monoclonal Antibody (3D2)

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HMGB2 Monoclonal Antibody (3D2)

Product Details

H00003148-M04

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL
-

Immunocytochemistry (ICC/IF)

10 µg/mL
-

ELISA (ELISA)

0.03 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

3D2

Immunogen

HMGB2 (AAH00903.2, 1 a.a. approximately 195 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEE

Target Information

HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: High mobility group protein 2; High mobility group protein B2; high-mobility group (nonhistone chromosomal) protein 2; HMG 2; HMG B2; HMG-2; HMG-B2; HMGB-2; unnamed protein product

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Gene Aliases: HMG2; HMGB2

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UniProt ID: (Human) P26583

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Entrez Gene ID: (Human) 3148

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Function(s)
four-way junction DNA binding transcription regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity RNA binding protein binding transcription factor binding DNA binding, bending protein domain specific binding chemoattractant activity non-sequence-specific DNA binding, bending RAGE receptor binding supercoiled DNA binding DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of endothelial cell proliferation immune system process inflammatory response to antigenic stimulus DNA topological change double-strand break repair via nonhomologous end joining DNA recombination chromatin organization nucleosome assembly chromatin remodeling regulation of transcription from RNA polymerase II promoter chemotaxis inflammatory response spermatogenesis spermatid nucleus differentiation male gonad development extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression negative regulation of gene expression DNA geometric change response to lipopolysaccharide positive regulation of interferon-beta production V(D)J recombination innate immune response positive regulation of innate immune response positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone regulation of neurogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive chemotaxis cell chemotaxis cellular response to lipopolysaccharide regulation of stem cell proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of hemopoiesis
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