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AbboMax
Phospho-Cytokeratin 8 (Ser431) Monoclonal Antibody (ABM271)
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FIGURE: 1 / 1
Phospho-Cytokeratin 8 (Ser431) Antibody (606-480) in IHC (P)
Immunohistochemistry: Human breast carcinoma (FFPE) stained with Mouse anti- Cytokeratin (pS431) (Cat# 606-480) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
606-480
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
ABM271
Immunogen
A synthetic peptide of Cytokeratin 7 protein with a phosphrylation site Serine 431
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM tris with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Breast carcinoma
Cellular location: Membrane and cytoplsm.
Target Information
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CK-8; cytokeratin 8; Cytokeratin endo A; Cytokeratin-8; K8; keratin 8, type II; keratin complex 2, basic, gene 8; Keratin, type II cytoskeletal 8; Keratin-8; Type-II keratin Kb8; unnamed protein product
Gene Aliases: AA960620; AL022697; AU019895; CARD2; CK-8; CK8; CYK8; EndoA; K2C8; K8; KO; Krt-2.8; Krt2-8; KRT8
UniProt ID: (Human) P05787, (Mouse) P11679
Entrez Gene ID: (Human) 3856, (Mouse) 16691
tumor necrosis factor-mediated signaling pathway
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell morphogenesis involved in differentiation
multicellular organism development
sarcomere organization
response to hydrostatic pressure
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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