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Invitrogen
ACVR2B (Bimagrumab Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-58424
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
1 mg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Target Information
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type IIB; Activin receptor type IIB; Activin receptor type-2B; ACTR-IIB; MGC116908; probable match to ACTIVIN RECEPTOR TYPE IIB PRECURSOR (ACTR-IIB)
Gene Aliases: ActR-IIB; ACTRIIB; ACVR2B; HTX4
UniProt ID: (Human) Q13705
Entrez Gene ID: (Human) 93
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
activin receptor activity, type II
transferase activity
activin-activated receptor activity
kinase activator activity
growth factor binding
metal ion binding
activin binding
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
gastrulation with mouth forming second
kidney development
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
cellular iron ion homeostasis
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
response to glucose
post-embryonic development
anterior/posterior pattern specification
regulation of signal transduction
insulin secretion
negative regulation of ossification
lung development
positive regulation of bone mineralization
BMP signaling pathway
pancreas development
developmental process
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
organ growth
odontogenesis of dentin-containing tooth
positive regulation of osteoblast differentiation
embryonic foregut morphogenesis
skeletal system morphogenesis
palate development
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
trophoblast cell migration
cellular response to growth factor stimulus
negative regulation of cold-induced thermogenesis
negative regulation of adipose tissue development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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