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Invitrogen
Phospho-ULK1 (Ser757) Recombinant Rabbit Monoclonal Antibody (RM488)
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Product Details
MA562162
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM488
Immunogen
A phospho-peptide corresponding to human phospho- ULk1 (Autophagy-related protein 1 homolog, ATG1) (Ser757).
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts to human ULK1 only when phosphorylated at Ser757. There is no cross-reactivity to ULK1 that is not phosphorylated. This antibody may also react to mouse or rat Phospho-ULK1 (Ser757) as predicted by immunogen homology.
Target Information
ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; Serine/threonine-protein kinase ULK1; ULK 1; UNC 51; Unc-51-like kinase 1
Gene Aliases: ATG1; ATG1A; hATG1; KIAA0722; ULK1; UNC51; Unc51.1
UniProt ID: (Human) O75385
Entrez Gene ID: (Human) 8408
autophagosome assembly
mitophagy
protein phosphorylation
ubiquitin-dependent protein catabolic process
autophagy
signal transduction
axonogenesis
protein localization
negative regulation of cell proliferation
regulation of autophagy
positive regulation of autophagy
regulation of tumor necrosis factor-mediated signaling pathway
macroautophagy
regulation of macroautophagy
peptidyl-serine phosphorylation
neuron projection regeneration
neuron projection development
negative regulation of protein complex assembly
cellular response to nutrient levels
cellular response to stress
piecemeal microautophagy of nucleus
response to starvation
protein autophosphorylation
negative regulation of collateral sprouting
axon extension
reticulophagy
protein-containing complex assembly
positive regulation of autophagosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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