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Rockland

Nrf2 Polyclonal Antibody

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Product Details

600-401-GT6S

Applications
Tested Dilution
Publications

Western Blot (WB)

1.0 µg/mL
-

ELISA (ELISA)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-NRF-2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding near the c-term region.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

25 µg

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity-purified antibody is directed against mouse Nrf2 protein. A BLAST analysis was used to suggest cross reactivity with Nrf2 proteins from human, mouse, rat and bovine based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

Target Information

Nfr1 (also designated TCF11), Nrf2 and Nfr3 are bZIP transcription factors that heterodimer with Maf proteins to bind MARE (Maf recognition elements) sequences. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E4TF1-60; E4TF1A; NF-E2-like basic leucine zipper transcriptional activator; NF-E2-related factor 2; NFE2-related factor 2; NFT2; NRF2; NRF2A; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2 like 2; Nuclear factor, erythroid derived 2, like 2; unnamed protein product

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Gene Aliases: AI194320; HEBP1; IMDDHH; NFE2L2; Nrf-2; NRF2

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UniProt ID: (Human) Q16236, (Mouse) Q60795

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Entrez Gene ID: (Human) 4780, (Mouse) 18024

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding ubiquitin protein ligase binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding molecular condensate scaffold activity RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding protein heterodimerization activity basic leucine zipper transcription factor
Process(es)
response to ischemia regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter inflammatory response response to oxidative stress response to xenobiotic stimulus gene expression proteasomal ubiquitin-independent protein catabolic process positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development protein ubiquitination positive regulation of blood coagulation endoplasmic reticulum unfolded protein response cellular response to oxidative stress response to endoplasmic reticulum stress PERK-mediated unfolded protein response cellular response to glucose starvation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of blood vessel endothelial cell migration regulation of innate immune response cell redox homeostasis positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development aflatoxin catabolic process positive regulation of glucose import cellular response to methionine response to caloric restriction cellular response to hydrogen peroxide cellular response to copper ion cellular response to tumor necrosis factor cellular response to hypoxia cellular response to xenobiotic stimulus cellular response to fluid shear stress cellular response to laminar fluid shear stress reactive oxygen species metabolic process negative regulation of ferroptosis integrated stress response signaling negative regulation of cellular response to hypoxia regulation of cellular response to oxidative stress negative regulation of hematopoietic stem cell differentiation negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of glutathione biosynthetic process positive regulation of ERAD pathway cellular response to angiotensin negative regulation of vascular associated smooth muscle cell migration positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of removal of superoxide radicals negative regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to drug positive regulation of transcription from RNA polymerase II promoter in response to stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress negative regulation of cell death negative regulation of hydrogen peroxide-induced cell death
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