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Angiopoietin 1 Polyclonal Antibody

View all (24) Angiopoietin 1 antibodies

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Angiopoietin 1 Polyclonal Antibody

Product Details

100-401-403S

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800
-

ELISA (ELISA)

1:5,000-1:25,000
-

Immunoprecipitation (IP)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide corresponding to a N-terminus region near aa 15-45 of mouse angiopoietin 1 protein conjugated to KLH using maleimide. A residue of cysteine was added to the amino terminal end to facilitate coupling.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

80 mg/mL

Amount

2 mg

Storage buffer

0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Anti-Angiopoietin 1 is directed against mouse angiopoietin-1 and shows no reactivity with mouse angiopoietin-2. This reagent cross-reacts with human angiopoietin 1. Partially cross reactivity is noted with human angiopoietin 2.

Target Information

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANG-1; Angiopoietin-1; KIAA0003; ligand for the TIE2 receptor; unnamed protein product

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Gene Aliases: 1110046O21Rik; AGP1; AGPT; AGPT-1; Ang-1; ANG1; ANGPT1; HAE5; KIAA0003

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UniProt ID: (Human) Q15389, (Mouse) O08538

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Entrez Gene ID: (Human) 284, (Mouse) 11600

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Function(s)
receptor binding protein binding receptor tyrosine kinase binding identical protein binding receptor agonist activity vascular endothelial growth factor receptor binding intercellular signal molecule
Process(es)
angiogenesis blood vessel development in utero embryonic development regulation of endothelial cell proliferation sprouting angiogenesis positive regulation of receptor internalization negative regulation of cytokine production involved in immune response negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity blood coagulation positive regulation of endothelial cell migration positive regulation of gene expression regulation of skeletal muscle satellite cell proliferation hemopoiesis cell differentiation negative regulation of blood coagulation heparin biosynthetic process positive regulation of protein ubiquitination cell-substrate adhesion regulation of tumor necrosis factor production protein localization to cell surface negative regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of vascular permeability regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration positive regulation of cell adhesion Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation positive regulation of coagulation positive chemotaxis positive regulation of multicellular organismal process neuron apoptotic process positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade glomerulus vasculature development negative regulation of vascular endothelial growth factor signaling pathway positive regulation of maintenance of permeability of blood-brain barrier negative regulation of endothelial cell apoptotic process regulation of macrophage migration inhibitory factor signaling pathway ovarian follicle development patterning of blood vessels vasculogenesis negative regulation of protein phosphorylation negative regulation of cytokine secretion involved in immune response endocardium morphogenesis multicellular organism development endoderm development positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation regulation of protein binding protein homooligomerization cardiac muscle tissue morphogenesis vasculogenesis involved in coronary vascular morphogenesis
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