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NeoBiotechnologies
Periostin (POSTN) Recombinant Rabbit Monoclonal Antibody (POSTN/8523R)
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Product Details
10631-RBM11-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
POSTN/8523R
Immunogen
Recombinant fragment (around aa193-326) of human POSTN protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion molecule; fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; periodontal ligament-specific periostin; Periostin; periostin, osteoblast specific factor; PN; RP11 412K4.1; RP11-412K4.1; unnamed protein product
Gene Aliases: OSF-2; OSF2; PDLPOSTN; PN; POSTN
UniProt ID: (Human) Q15063
Entrez Gene ID: (Human) 10631
response to hypoxia
negative regulation of cell-matrix adhesion
regulation of systemic arterial blood pressure
cell adhesion
regulation of Notch signaling pathway
response to mechanical stimulus
tissue development
response to muscle activity
positive regulation of smooth muscle cell migration
extracellular matrix organization
response to estradiol
cellular response to fibroblast growth factor stimulus
cellular response to vitamin K
cellular response to tumor necrosis factor
cellular response to transforming growth factor beta stimulus
negative regulation of substrate adhesion-dependent cell spreading
neuron projection extension
bone regeneration
positive regulation of chemokine (C-X-C motif) ligand 2 production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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