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Invitrogen
PAR2 Monoclonal Antibody (SAM11)
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FIGURE: 1 / 5
PAR2 Antibody (35-2300) in ICC/IF
Cell communication and signaling : CCS 2018 -
Fig. 5 Expression of PAR2 in HFL-1 cells. RTqPCR was used to confirm the expression of the serine protease receptor PAR2 on HFL-1. The relative gene expression was related to the housekeeping gene 18 s ( n = 2, 1 experiment). Human lung fibroblasts, HFL-1, showed a high gene expression for PAR2, while LAD2 cells did not show any PAR2 gene expression ( a ). Expression of PAR2 examined in monolayer cultures o... View More
Product Details
35-2300
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
SAM11
Immunogen
A synthetic peptide corresponding to the N-terminal of the human PAR2 receptor.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; G-protein-coulped receptor; PAR-2; PAR-2; protease-activated receptor 2; Proteinase-activated receptor 2; Thrombin receptor-like 1
Gene Aliases: F2RL1; GPR11; PAR2
UniProt ID: (Human) P55085
Entrez Gene ID: (Human) 2150
T cell activation involved in immune response
immune system process
positive regulation of leukocyte chemotaxis
positive regulation of cytokine production involved in immune response
positive regulation of glomerular filtration
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
blood coagulation
negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of blood coagulation
positive regulation of cell migration
positive regulation of actin filament depolymerization
positive regulation of pseudopodium assembly
negative regulation of chemokine production
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of Rho protein signal transduction
neutrophil activation
vasodilation
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of eosinophil degranulation
positive regulation of GTPase activity
innate immune response
cell-cell junction maintenance
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
negative regulation of JNK cascade
positive regulation of JNK cascade
negative regulation of insulin secretion
leukocyte migration
positive regulation of chemotaxis
positive regulation of positive chemotaxis
defense response to virus
positive regulation of protein kinase B signaling
positive regulation of phagocytosis, engulfment
establishment of endothelial barrier
regulation of biological quality
positive regulation of ERK1 and ERK2 cascade
thrombin receptor signaling pathway
leukocyte proliferation
positive regulation of neutrophil mediated killing of gram-negative bacterium
mature conventional dendritic cell differentiation
positive regulation of renin secretion into blood stream
regulation of chemokine (C-X-C motif) ligand 2 production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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