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Invitrogen
Connexin 30 Polyclonal Antibody (Z-PP9)
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FIGURE: 1 / 90
Connexin 30 Antibody (71-2200) in ICC/IF
Immunofluorescence analysis of Connexin-30 was done on 70% confluent log phase Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Connexin-30 Rabbit polyclonal Antibody (Product # 71-2200) at 2 µg/mL in 1% BSA and incubated for 3 hours at room te... View More
Product Details
71-2200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Human,
Mouse,
Rat
Published species
Cat,
Chicken,
Guinea pig,
Human,
Mouse,
Non-human primate,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Clone
Z-PP9
Immunogen
A synthetic peptide derived from the unique C-terminus of the mouse Connexin 30 protein
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is specific for the Connexin 30. Cross-reactivity with the highly related Connexin 26 protein or with other Connexin family members has not been detected. Reactivity of this antibody has been confirmed by western blotting using cell lysates derived from adult rat, mouse, human, and cat brains.
Target Information
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: connexin 30; Connexin-30; Cx30; ectodermal dysplasia 2, hidrotic (Clouston syndrome); Gap junction beta-6 protein; gap junction membrane channel protein beta 6; gap junction protein beta 6; gap junction protein, beta 6 (connexin 30); gap junction protein, beta 6, 30kDa; unnamed protein product
Gene Aliases: AA958971; CX30; Cxn-30; D14Bwg0506e; DFNA3; DFNA3B; DFNB1B; ECTD2; ED2; EDH; GJB6; HED; HED2
UniProt ID: (Human) O95452, (Mouse) P70689
Entrez Gene ID: (Human) 10804, (Mouse) 14623, (Rat) 84403
sinoatrial node development
cell communication
cell-cell signaling
sensory perception of sound
negative regulation of cell proliferation
cell communication by electrical coupling
gap junction assembly
response to lipopolysaccharide
maintenance of blood-brain barrier
ear morphogenesis
inner ear development
response to electrical stimulus
transmembrane transport
cellular response to glucose stimulus
gap junction-mediated intercellular transport
apoptotic process
aging
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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