TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody (TNF706)

transcription regulatory region sequence-specific DNA binding protease binding cytokine activity tumor necrosis factor receptor binding protein binding death receptor agonist activity identical protein binding receptor agonist activity transcription regulatory region DNA binding

protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPKKK activity activation of MAPK activity response to hypoxia cell activation positive regulation of cytokine production regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of L-glutamate transport chronic inflammatory response to antigenic stimulus negative regulation of cytokine secretion involved in immune response positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin skeletal muscle contraction glucose metabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process obsolete transformed cell apoptotic process defense response inflammatory response humoral immune response signal transduction JNK cascade multicellular organism development negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to radiation response to mechanical stimulus response to virus organ morphogenesis positive regulation of gene expression negative regulation of gene expression negative regulation of alkaline phosphatase activity response to activity calcium-mediated signaling extracellular matrix organization osteoclast differentiation sequestering of triglyceride positive regulation of protein complex assembly positive regulation of fever generation lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide negative regulation of interleukin-6 production positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-18 production positive regulation of interleukin-6 production receptor biosynthetic process positive regulation of peptidyl-serine phosphorylation tumor necrosis factor-mediated signaling pathway positive regulation of heterotypic cell-cell adhesion regulation of cell proliferation positive regulation of NF-kappaB import into nucleus response to drug defense response to bacterium positive regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of protein complex disassembly positive regulation of protein complex disassembly positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process negative regulation of growth of symbiont in host negative regulation of viral genome replication positive regulation of chemokine biosynthetic process cellular extravasation positive regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process negative regulation of myoblast differentiation negative regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of action potential positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron negative regulation of glucose import positive regulation of JNK cascade embryonic digestive tract development positive regulation of smooth muscle cell proliferation regulation of protein secretion positive regulation of cytokine secretion positive regulation of inflammatory response positive regulation of phagocytosis regulation of insulin secretion positive regulation of synaptic transmission defense response to Gram-positive bacterium leukocyte migration leukocyte tethering or rolling detection of mechanical stimulus involved in sensory perception of pain negative regulation of lipid catabolic process regulation of immunoglobulin secretion positive regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein transport response to glucocorticoid positive regulation of NFAT protein import into nucleus positive regulation of hair follicle development positive regulation of protein kinase B signaling positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of branching involved in lung morphogenesis cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to nicotine cellular response to organic cyclic compound positive regulation of podosome assembly apoptotic signaling pathway extrinsic apoptotic signaling pathway necroptotic signaling pathway response to gold nanoparticle positive regulation of protein localization to cell surface positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand immune response cell proliferation positive regulation of cell proliferation positive regulation of cell adhesion microglial cell activation negative regulation of endothelial cell proliferation macrophage activation involved in immune response regulation of immunoglobulin production positive regulation of immunoglobulin production negative regulation of cytokine production involved in immune response negative regulation of systemic arterial blood pressure JAK-STAT cascade circadian rhythm response to xenobiotic stimulus response to bacterium response to salt stress response to fructose negative regulation of heart rate vascular endothelial growth factor production positive regulation of macrophage derived foam cell differentiation negative regulation of lipid storage regulation of metabolic process positive regulation of defense response negative regulation of myelination response to nutrient levels positive regulation of fractalkine production positive regulation of interleukin-1 beta production positive regulation of interleukin-8 production toll-like receptor 3 signaling pathway positive regulation of cellular amide metabolic process response to isolation stress response to macrophage colony-stimulating factor NIK/NF-kappaB signaling vasodilation negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of blood vessel endothelial cell migration innate immune response response to ethanol regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of lipid metabolic process negative regulation of mitotic cell cycle astrocyte activation regulation of inflammatory response negative regulation of neurogenesis regulation of developmental process modulation of synaptic transmission regulation of synapse organization cognition regulation of secretion regulation of multicellular organismal process regulation of synaptic transmission, glutamatergic positive regulation of glial cell proliferation negative regulation of vascular wound healing regulation of biological quality positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to molecule of bacterial origin cellular response to retinoic acid cellular response to interferon-gamma cellular response to ionizing radiation positive regulation of mononuclear cell migration endothelial cell apoptotic process protein localization to plasma membrane negative regulation of oxidative phosphorylation inflammatory response to wounding cellular response to toxic substance liver regeneration negative regulation of bile acid secretion antiviral innate immune response response to Gram-negative bacterium positive regulation of neuroinflammatory response positive regulation of interleukin-33 production positive regulation of cytokine production involved in inflammatory response negative regulation of beta-amyloid clearance positive regulation of NIK/NF-kappaB signaling positive regulation of synoviocyte proliferation positive regulation of beta-amyloid formation response to L-glutamate positive regulation of neutrophil activation negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to plasma membrane regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of cellular protein localization cellular response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell regulation of membrane lipid metabolic process response to 3,3',5-triiodo-L-thyronine positive regulation of blood microparticle formation positive regulation of hepatocyte proliferation regulation of endothelial cell apoptotic process positive regulation of DNA biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway cortical actin cytoskeleton organization negative regulation of myosin-light-chain-phosphatase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of superoxide dismutase activity positive regulation of I-kappaB phosphorylation negative regulation of production of miRNAs involved in gene silencing by miRNA