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Abnova
IFNA2 Monoclonal Antibody (1D3)
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Product Details
H00003440-M39A
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1D3
Immunogen
IFNA2 (NP_000596, 24 a.a. approximately 188 a.a) partial recombinant protein.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2a interferon; cytokine; IFN-a; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFNA 2; IFNA2; IFNA2b; Interferon; interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha-2; Interferon alpha-A; interferon alpha-D; Interferon-alpha II; LeIF A; leIF D; RP11-354P17.2; unnamed protein product
Gene Aliases: IFN-alpha-2; IFN-alphaA; IFNA; IFNA2; IFNA2A; IFNA2B; IFNA2C; leIF A
UniProt ID: (Human) P01563
Entrez Gene ID: (Human) 3440
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
apoptotic process
defense response
inflammatory response
humoral immune response
cell surface receptor signaling pathway
cell-cell signaling
negative regulation of gene expression
negative regulation of interleukin-13 production
negative regulation of interleukin-5 production
response to exogenous dsRNA
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
defense response to virus
type I interferon signaling pathway
receptor signaling pathway via STAT
cellular response to virus
negative regulation of T-helper 2 cell cytokine production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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