Muscimol, conjugado BODIPY™ TMR-X
Muscimol, conjugado BODIPY™ TMR-X
Citas y referencias (14)
Invitrogen™

Muscimol, conjugado BODIPY™ TMR-X

El muscimol es un agonista poderoso del receptor GABAA y ha sido ampliamente utilizado para desactivar de manera reversible gruposMás información
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Número de catálogoCantidad
M234001 mg
Número de catálogo M23400
Precio (MXN)
-
Cantidad:
1 mg
El muscimol es un agonista poderoso del receptor GABAA y ha sido ampliamente utilizado para desactivar de manera reversible grupos localizados de neuronas. El conjugado BODIPY TMR-X de muscimol puede usarse, en lugar de reactivos y métodos radioactivos, para mapear la distribución del muscimol en el sistema nervioso, así como para detectar la presencia de receptores GABAA en las superficies celulares.
Para uso exclusivo en investigación. No apto para uso en procedimientos diagnósticos.
Especificaciones
Método de detecciónFluorescente
Excitación/emisión543/572 nm
Para utilizar con (equipo)Microscopio de fluorescencia
Fórmula molecularC31H36BF2N5O5
Peso molecular607.46
Línea de productosBODIPY
Cantidad1 mg
Almacenamiento recomendadoAlmacenar en el congelador (de -5 °C a -30 °C) y proteger de la luz.
Condiciones de envíoTemperatura ambiente
ColorAmarillo
Forma físicaSólido
Tipo de productoMuscimol
Unit SizeEach

Citations & References (14)

Citations & References
Abstract
Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment.
Authors:Vu TQ, Chowdhury S, Muni NJ, Qian H, Standaert RF, Pepperberg DR,
Journal:Biomaterials
PubMed ID:15576163
'The derivatization of surfaces with bioactive molecules is a research area of growing importance for cell and tissue engineering. Tetherable molecules used in such applications must contain an anchoring moiety as well as the biofunctional group, typically along with a spacer to prevent steric clashes between the target molecule and ... More
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction.
Authors:Borodinsky LN, Spitzer NC
Journal:Proc Natl Acad Sci U S A
PubMed ID:17190810
'Signaling in the nervous system requires matching of neurotransmitter receptors with cognate neurotransmitters at synapses. The vertebrate neuromuscular junction is the best studied cholinergic synapse, but the mechanisms by which acetylcholine is matched with acetylcholine receptors are not fully understood. Because alterations in neuronal calcium spike activity alter transmitter specification ... More
Imaging the spread of reversible brain inactivations using fluorescent muscimol.
Authors:Allen TA, Narayanan NS, Kholodar-Smith DB, Zhao Y, Laubach M, Brown TH,
Journal:J Neurosci Methods
PubMed ID:18377997
Muscimol is a GABA A-agonist that causes rapid and reversible suppression of neurophysiological activity. Interpretations of the effects of muscimol infusions into the brain have been limited because of uncertainty about spread of the drug around the injection site. To solve this problem, the present study explored the use of ... More
GABA(A) receptor binding and localization in the tiger salamander retina.
Authors:Wang H, Standifer KM, Sherry DM
Journal:Vis Neurosci
PubMed ID:10750823
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the retina and also appears to act as a trophic factor regulating photoreceptor development and regeneration. Although the tiger salamander is a major model system for the study of retinal circuitry and regeneration, our understanding of GABA receptors in this species ... More
A cross-modality enhancement of defensive flight via parvalbumin neurons in zona incerta.
Authors:
Journal:Elife
PubMed ID:30985276
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