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Invitrogen
DPM1 Polyclonal Antibody
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Product Details
PA5-121135
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DPM1 (NP_003850.1).
Conjugate
Form
Liquid
Concentration
1.44 mg/mL
Amount
144 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: NCI-H460, HeLa, SKOV3, Mouse pancreas, Mouse liver, Mouse kidney, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum.
Immunogen sequence: MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS FSESGINYEI IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT AYIHGMKHAT GNYIIIMDAD LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG NGGVYGWDLK RKIISRGANF LTQILLRPGA SDLTGSFRLY RKEVLEKLIE KCVSKGYVFQ MEMIVRARQL NYTIGEVPIS FVDRVYGESK LGGNEIVSFL KGLLTLFATT
Target Information
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dolichol monophosphate mannose synthase; dolichol-phosphate (beta-D) mannosyltransferase 1; Dolichol-phosphate mannose synthase subunit 1; Dolichol-phosphate mannosyltransferase subunit 1; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase 1; dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit; DPM synthase complex, catalytic subunit; DPM synthase subunit 1; DPM1; Mannose-P-dolichol synthase subunit 1; MPD synthase; MPD synthase subunit 1; OTTMUSP00000017164; RP23-391M18.1; unnamed protein product
Gene Aliases: AI118379; AI194292; CDGIE; DPM1; MPDS
UniProt ID: (Human) O60762, (Mouse) O70152
Entrez Gene ID: (Human) 8813, (Rat) 296394, (Mouse) 13480
dolichyl-phosphate beta-D-mannosyltransferase activity
protein binding
mannose binding
transferase activity
transferase activity, transferring glycosyl groups
alcohol binding
metal ion binding
dolichyl-phosphate-mannose-protein mannosyltransferase activity
glycosyltransferase
transferase
metabolite interconversion enzyme
protein glycosylation
dolichol-linked oligosaccharide biosynthetic process
GPI anchor biosynthetic process
protein N-linked glycosylation via asparagine
dolichol metabolic process
GDP-mannose metabolic process
protein mannosylation
protein O-linked mannosylation
response to oxygen levels
dolichol phosphate mannose biosynthetic process
mannosylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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