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Invitrogen
ERCC8 Monoclonal Antibody (OTI5C9)
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FIGURE: 1 / 2
ERCC8 Antibody (MA5-27019) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human embryonic brain cortex tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a ERCC8 monoclonal antibody (Product # MA5-27019) at a dilution of 1:150.
Product Details
MA5-27019
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5C9
Immunogen
Full length human recombinant protein of ERCC8 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKN1; Cockayne syndrome WD repeat protein CSA; Cockayne syndrome WD-repeat protein CSA; DNA excision repair protein ERCC-8; excision repair cross-complementation group 8; excision repair cross-complementing rodent repair deficiency, complementation group 8; unnamed protein product
Gene Aliases: CKN1; CSA; ERCC8; UVSS2
UniProt ID: (Human) Q13216
Entrez Gene ID: (Human) 1161
single strand break repair
protein polyubiquitination
DNA repair
transcription-coupled nucleotide-excision repair
cellular response to DNA damage stimulus
response to oxidative stress
response to UV
response to X-ray
response to auditory stimulus
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA repair
protein autoubiquitination
regulation of transcription-coupled nucleotide-excision repair
double-strand break repair via classical nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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