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Invitrogen
HINT1 Recombinant Rabbit Monoclonal Antibody (JE63-55)
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FIGURE: 1 / 4
HINT1 Antibody (MA5-44791) in IHC (P)
Immunohistochemistry analysis of HINT1 in paraffin-embedded rat epididymis tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with HINT1 Monoclonal antibody (Product # MA5-44791) using a dilution of 1:400 for 1 hour at roo... View More
Product Details
MA5-44791
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE63-55
Immunogen
Synthetic peptide within human HINT1 aa 1-50/126.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17 kDa inhibitor of protein kinase C; adenosine 5'-monophosphoramidase; Adenosine 5'-monophosphoramidase HINT1; Desumoylating isopeptidase HINT1; epididymis secretory sperm binding protein; FLJ30414; FLJ32340; HINT1; Histidine triad nucleotide-binding protein 1; PKC inhibitor/ interacting protein; PKCI-1; Protein kinase C inhibitor 1; protein kinase C, iota; Protein kinase C-interacting protein 1; unnamed protein product
Gene Aliases: AA673479; HINT; HINT1; Ipk1; NMAN; Pkci; PKCI-1; PKCI1; Prkci; PRKCNH1
UniProt ID: (Human) P49773, (Mouse) P70349, (Rat) P62959
Entrez Gene ID: (Human) 3094, (Mouse) 15254, (Rat) 690660
nucleotide binding
catalytic activity
protein kinase C binding
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
SUMO-specific protease activity
adenosine 5'-monophosphoramidase activity
GPI-anchor transamidase activity
coenzyme F390-A hydrolase activity
coenzyme F390-G hydrolase activity
nucleotide phosphatase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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