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Invitrogen

SLC27A1 Polyclonal Antibody

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SLC27A1 Polyclonal Antibody

Product Details

PA5-102890

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SLC27A1(Accession Q6PCB7), corresponding to amino acid residues S482-L532.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2852272

Product Specific Information

Antibody detects endogenous levels of total FATP1.

Target Information

SLC27A1 is a protein coding gene. Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACSVL5FATP-1; Arachidonate--CoA ligase; EC 6.2.1; FATP-1; Fatty acid transport protein; Fatty acid transport protein 1; FLJ00336; Long-chain fatty acid transport protein 1; Long-chain-fatty-acid--CoA ligase; MGC71751; solute carrier family 27 (fatty acid transporter), member 1; Solute carrier family 27 member 1; solute carrier family 27, member 1; unnamed protein product; Very long-chain acyl-CoA synthetase; Vlc27a1

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Gene Aliases: ACSVL5; FATP; FATP-1; FATP1; SLC27A1

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UniProt ID: (Human) Q6PCB7, (Mouse) Q60714

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Entrez Gene ID: (Human) 376497, (Rat) 94172, (Mouse) 26457

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Function(s)
nucleotide binding long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity protein binding biotin transporter activity fatty acid transporter activity efflux transmembrane transporter activity ligase activity very long-chain fatty acid-CoA ligase activity identical protein binding protein serine/threonine kinase activator activity arachidonate-CoA ligase activity oleoyl-CoA ligase activity protein homodimerization activity catalytic activity acyl-CoA ligase activity succinate-CoA ligase activity 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity fatty acid ligase activity 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity benzoyl acetate-CoA ligase activity 2,4-dichlorobenzoate-CoA ligase activity pivalate-CoA ligase activity cyclopropanecarboxylate-CoA ligase activity adipate-CoA ligase activity citronellyl-CoA ligase activity mentha-1,3-dione-CoA ligase activity thiophene-2-carboxylate-CoA ligase activity 2,4,4-trimethylpentanoate-CoA ligase activity cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity branched-chain acyl-CoA synthetase (ADP-forming) activity aryl-CoA synthetase (ADP-forming) activity 3-hydroxypropionyl-CoA synthetase activity perillic acid:CoA ligase (ADP-forming) activity perillic acid:CoA ligase (AMP-forming) activity (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity pristanate-CoA ligase activity malonyl-CoA synthetase activity transporter secondary carrier transporter
Process(es)
medium-chain fatty acid transport long-chain fatty acid metabolic process lipid metabolic process fatty acid metabolic process lipid transport response to cold positive regulation of triglyceride biosynthetic process biotin transport fatty acid transport long-chain fatty acid transport plasma membrane long-chain fatty acid transport positive regulation of heat generation response to insulin adiponectin-activated signaling pathway glucose import in response to insulin stimulus long-chain fatty acid import export across plasma membrane transport across blood-brain barrier biotin import across plasma membrane lipid transport across blood brain barrier phosphatidylethanolamine biosynthetic process phosphatidic acid biosynthetic process phosphatidylglycerol biosynthetic process phosphatidylcholine biosynthetic process phosphatidylserine biosynthetic process phosphatidylinositol biosynthetic process biological_process cardiolipin biosynthetic process negative regulation of phospholipid biosynthetic process positive regulation of protein serine/threonine kinase activity transport metabolic process
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