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NeoBiotechnologies
DBH/Dopamine Beta-Hydroxylase Monoclonal Antibody (DBH/7224)
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Product Details
1621-MSM4-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2, kappa
Class
Monoclonal
Type
Antibody
Clone
DBH/7224
Immunogen
Recombinant fragment (around aa200-400) of human DBH protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:Human adrenal gland or adrenal pheochromocytoma.
Cellular Location: Cytoplasm.
Target Information
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; Dopamine-Beta-hydroxylase; unnamed protein product
Gene Aliases: DBH; DBM; ORTHYP1
UniProt ID: (Human) P09172
Entrez Gene ID: (Human) 1621
catalytic activity
monooxygenase activity
dopamine beta-monooxygenase activity
copper ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
L-ascorbic acid binding
metal ion binding
blood vessel remodeling
response to amphetamine
leukocyte mediated immunity
octopamine biosynthetic process
chemical synaptic transmission
memory
locomotory behavior
associative learning
visual learning
homoiothermy
vasoconstriction
dopamine catabolic process
norepinephrine biosynthetic process
catecholamine biosynthetic process
glucose homeostasis
fear response
maternal behavior
positive regulation of vasoconstriction
behavioral response to ethanol
response to pain
leukocyte migration
positive regulation of cold-induced thermogenesis
regulation of vascular associated smooth muscle cell proliferation
regulation of vascular endothelial cell proliferation
regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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