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Invitrogen

alpha Actinin 1/2/3/4 Polyclonal Antibody

View all (3) alpha Actinin 1/2/3/4 antibodies

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alpha Actinin 1/2/3/4 Polyclonal Antibody

Product Details

PA5-103181

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ACTN1(Accession P12814), corresponding to amino acid residues Q167-D217.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2815957

Product Specific Information

Antibody detects endogenous levels of total ACTN1/2/3/4.

Target Information

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: actinin 1 smooth muscle; alpha actinin 1a; alpha actinin 4; Alpha-actinin cytoskeletal isoform; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-1; Alpha-actinin-2; Alpha-actinin-3; Alpha-actinin-4; epididymis secretory sperm binding protein; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; non-muscle alpha-actinin 1; Non-muscle alpha-actinin 4; Non-muscle alpha-actinin-1; transcriptional coactivator; unnamed protein product

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Gene Aliases: 1110008F24Rik; 3110023F10Rik; ACTININ-4; ACTN1; Actn1a; ACTN2; ACTN3; ACTN3D; ACTN4; BDPLT15; C77391; CMD1AA; CMH23; CMYO8; CMYP8; FSGS; FSGS1; MPD6; MYOCOZ

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UniProt ID: (Human) P12814, (Human) P35609, (Human) Q08043, (Human) O43707, (Rat) Q9Z1P2, (Mouse) Q7TPR4, (Mouse) Q9JI91, (Mouse) O88990, (Mouse) P57780, (Rat) Q9QXQ0

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Entrez Gene ID: (Human) 87, (Human) 88, (Human) 89, (Human) 81, (Rat) 81634, (Mouse) 109711, (Mouse) 11472, (Rat) 291245, (Mouse) 11474, (Rat) 171009, (Mouse) 60595, (Rat) 63836

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Function(s)
transcription coactivator activity double-stranded RNA binding actin binding integrin binding calcium ion binding protein binding cytoskeletal protein binding vinculin binding identical protein binding protein homodimerization activity ion channel binding metal ion binding actin filament binding structural constituent of postsynapse phosphatidylinositol-4,5-bisphosphate binding structural constituent of muscle protein domain specific binding LIM domain binding titin binding FATZ binding titin Z domain binding structural constituent of postsynaptic actin cytoskeleton channel activator activity RNA polymerase II regulatory region sequence-specific DNA binding nucleoside binding RNA binding ligand-dependent nuclear receptor binding chromatin DNA binding retinoic acid receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity protein binding, bridging protein dimerization activity protein complex binding nuclear hormone receptor binding poly(A) RNA binding protein N-terminus binding
Process(es)
regulation of the force of skeletal muscle contraction skeletal muscle atrophy transition between fast and slow fiber response to denervation involved in regulation of muscle adaptation actin cytoskeleton organization positive regulation of fast-twitch skeletal muscle fiber contraction regulation of apoptotic process negative regulation of glycolytic process focal adhesion assembly positive regulation of skeletal muscle tissue growth positive regulation of skeletal muscle fiber development muscle cell development bone morphogenesis negative regulation of calcineurin-NFAT signaling cascade regulation of muscle system process negative regulation of oxidative phosphorylation negative regulation of cold-induced thermogenesis positive regulation of bone mineralization involved in bone maturation negative regulation of relaxation of muscle regulation of aerobic respiration positive regulation of glucose catabolic process to lactate via pyruvate actin filament bundle assembly negative regulation of cellular component movement actin crosslink formation regulation of nucleic acid-templated transcription cortical cytoskeleton organization muscle contraction microspike assembly regulation of membrane potential negative regulation of potassium ion transport positive regulation of potassium ion transport protein homotetramerization negative regulation of potassium ion transmembrane transporter activity positive regulation of potassium ion transmembrane transporter activity negative regulation of protein localization to cell surface positive regulation of receptor activity transport protein transport peroxisome proliferator activated receptor signaling pathway retinoic acid receptor signaling pathway positive regulation of pinocytosis positive regulation of cellular component movement bicellular tight junction assembly protein localization to bicellular tight junction cell adhesion sarcomere organization positive regulation of transcription, DNA-templated anatomical structure formation involved in morphogenesis actin filament uncapping cardiac muscle cell development protein localization to plasma membrane phospholipase C-activating angiotensin-activated signaling pathway postsynaptic actin cytoskeleton organization positive regulation of endocytic recycling response to hypoxia vesicle transport along actin filament positive regulation of cell migration positive regulation of sodium:proton antiporter activity tumor necrosis factor-mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter negative regulation of substrate adhesion-dependent cell spreading positive regulation of NIK/NF-kappaB signaling actin filament organization platelet activation platelet formation platelet morphogenesis actin filament network formation platelet aggregation postsynapse organization
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