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Invitrogen

TBX2/3 Polyclonal Antibody

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TBX2/3 Polyclonal Antibody

Product Details

PA5-116010

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TBX3(Accession O15119), corresponding to amino acid residues A283-N333.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900644

Product Specific Information

Antibody detects endogenous levels of total TBX 2/3.

Target Information

TBX2 (T-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with TBX2 include Vertebral Anomalies And Variable Endocrine And T-Cell Dysfunction and Ulnar-Mammary Syndrome. Among its related pathways are Heart Development and Inhibition of Ribosome Biogenesis by p14(ARF). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TBX3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bladder cancer related protein XHL; T-box 2; T-box 3; T-box 3 (ulnar mammary syndrome); T-box gene; T-box protein 2; T-box protein 3; T-box transcription factor TBX2; T-box transcription factor TBX3; TBX2; TBX3; TBX3/2; unnamed protein product

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Gene Aliases: D5Ertd189e; TBX2; TBX3; TBX3-ISO; UMS; VETD; XHL

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UniProt ID: (Human) Q13207, (Human) O15119, (Mouse) Q60707, (Mouse) P70324, (Rat) Q7TST9

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Entrez Gene ID: (Human) 6909, (Human) 6926, (Mouse) 21385, (Rat) 303398, (Mouse) 21386, (Rat) 353305

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone deacetylase binding sequence-specific DNA binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding RNA polymerase II sequence-specific DNA binding transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding molecular_function Rel homology transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell fate specification heart looping heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis endocardial cushion formation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process Notch signaling pathway muscle cell fate determination regulation of heart contraction fibroblast growth factor receptor signaling pathway neurogenesis response to retinoic acid embryonic heart tube development aorta morphogenesis atrioventricular canal development embryonic digit morphogenesis pigment metabolic process involved in pigmentation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic camera-type eye morphogenesis cardiac muscle tissue development smooth muscle cell differentiation palate development pharyngeal system development positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation epithelial tube branching involved in lung morphogenesis developmental growth involved in morphogenesis mammary placode formation mesenchymal cell proliferation involved in lung development cellular response to dexamethasone stimulus ureteric peristalsis cochlea morphogenesis cellular senescence melanocyte proliferation negative regulation of heart looping negative regulation of cardiac chamber formation positive regulation of cell cycle G1/S phase transition cardiac jelly development atrioventricular canal morphogenesis negative regulation of cellular senescence skeletal system development blood vessel development in utero embryonic development atrioventricular bundle cell differentiation transcription, DNA-templated positive regulation of cell proliferation anterior/posterior axis specification, embryo organ morphogenesis specification of organ position stem cell population maintenance limbic system development male genitalia development female genitalia development negative regulation of epithelial cell differentiation mammary gland development regulation of protein stability luteinizing hormone secretion limb morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis forelimb morphogenesis regulation of cell proliferation inner ear morphogenesis negative regulation of apoptotic process negative regulation of myoblast differentiation positive regulation of cell cycle follicle-stimulating hormone secretion mesoderm morphogenesis semicircular canal morphogenesis cardiac muscle cell differentiation cardiac epithelial to mesenchymal transition ventricular septum morphogenesis branching involved in mammary gland duct morphogenesis cardiac muscle cell fate commitment sinoatrial node cell development hepatoblast differentiation regulation of protein complex stability stem cell proliferation negative regulation of cell proliferation involved in heart morphogenesis positive regulation of stem cell proliferation negative regulation of stem cell differentiation regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation transcription from RNA polymerase II promoter multicellular organism development cell aging pharynx development
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